Frontiers in Clinical Drug Research - Alzheimer Disorders

Volume 4

by

Atta-ur-Rahman

DOI: 10.2174/97816810814721150401
eISBN: 978-1-68108-147-2, 2015
ISBN: 978-1-68108-148-9
ISSN: 2451-8743 (Print)
ISSN: 2214-5168 (Online)



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Indexed in: EBSCO.

Frontiers in Clinical Drug Research - Alzheimer Disorders is an e-Book series concerned with Alzheimer's disease (AD)...[view complete introduction]

Table of Contents

Preface

- Pp. i-ii (2)

Atta-ur-Rahman

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List of Contributors

- Pp. iii

Atta-ur-Rahman

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Melatoninergic Pathways in Alzheimer's Disease

- Pp. 3-49 (47)

George Anderson and Michael Maes

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Pharmaceutical and Nutritional Benefits in Alzheimer's Disease via Convergence on the Melatoninergic Pathways

- Pp. 50-127 (78)

George Anderson and Michael Maes

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Some Questions Posed About the Prevention and Treatment of Alzheimer’s Disease

- Pp. 128-175 (48)

Margaret M. Esiri and Gordon K. Wilcock

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Current and Investigational Drugs for Treatment of Alzheimer's Disease

- Pp. 176-235 (60)

Pamela E. Potter

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Nutritional Approaches in Alzheimer's Disease Prevention

- Pp. 236-260 (25)

Lili Chen, Shishu Huang, Zhi-Gang Zhang, Cheung Toa Ng, Yat-Fung Shea, Leung-Wing Chu, Liqiu Wang, Yan Li and You-Qiang Song

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Subject Index

- Pp. 261-262 (2)

Atta-ur-Rahman

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Preface

Alzheimer’s disease (AD) is the most common age-related multifactorial neurodegenerative disease which is described as the failure of cognitive performance and behavioral capabilities. The clinical features of Alzheimer’s disease (AD) are worsening cognition with progressive discrepancy in recovery of memory. The book series, “Frontiers in Clinical Drug Research – Alzheimer Disorders”, is intended to present the most important advancements in the field in the form of cutting edge reviews written by experts in this field of research. Volume 4 of this eBook series is a compilation of five well written chapters contributed by prominent researchers which include topics such as, the role of melatoninergic pathways, investigational drugs and nutritional approaches in the prevention and treatment of Alzheimer’s disease.

Anderson and Maes in Chapter 1 review the role of melatoninergic pathways in Alzheimer's disease. They also discuss the influence of primary and secondary sites of infection in the etiology and course of AD. In chapter 2, they describe the role of melatonin in more detail with respect to the changes and interventions relevant to AD.

Many researchers are aiming at understanding, preventing and curing AD. Several strategies are being studied for developing therapies against this disorder. Esiri and Wilcock, in Chapter 3 discuss the various approaches for the treatment and prevention of Alzheimer’s disease. This review also describes the primary and secondary prevention of AD and the links with cardiovascular disease, diet and other lifestyle-related risks.

Neuritic plaques containing β-amyloid and neurofibrillary tangles containing tau are the two key targets of drugs under investigation that could prevent or slow down the progress of Alzheimer’s disease. Pamela E. Potter, in Chapter 4, comprehensively explains the mechanism of action and results of clinical trials for the drugs that have been recently used or that are in development for the treatment and management of Alzheimer’s disease.

The role of adequate nutrition in the management of mild cognitive impairment (MCI) and Alzheimer's disease (AD) is extensively reviewed in Chapter 5 by Chen et al. This review also discusses the role of several natural products including micronutrients in the nutritional prevention of AD.

The 4th volume of the book series presents important recent researches that have been reviewed comprehensively by eminent researchers. I wish to express my gratitude to the contributors as well as the editorial staff, particularly Mr. Mahmood Alam (Director Publication), Mr. Shehzad Naqvi (Senior Manager Publications) and Ms. Fariya Zulfiqar (Assistant Manager Publications) for their hard work and persistent efforts.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Kings College, University of Cambridge
Cambridge
UK




Contributor(s):
Cheung Toa Ng
School of Biomedical Sciences
The University of Hong Kong, Pokfulam
Hong Kong
China


George Anderson
CRC Scotland & London
Eccleston Square
London
UK


Gordon K. Wilcock
Nuffield Department of Clinical Neurosciences
Oxford University
UK


Leung-Wing Chu
Department of Medicine, LKS Faculty of Medicine
University of Hong Kong, Queen Mary Hospital
Hong Kong
China
/
Alzheimer’s Disease Research Network, SRT Aging
The University of Hong Kong
Hong Kong
China


Lili Chen
Center for Human Tissues and Organs Degeneration
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
Shenzhen
China


Liqiu Wang
Department of Mechanical Engineering
The University of Hong Kong
Hong Kong
China
/
HKU-Zhejiang Institute of Research and Innovation (HKU-ZIRI)
Linan 311100
Zhejiang
China


Margaret M. Esiri
Nuffield Department of Clinical Neurosciences
Oxford University
UK


Michael Maes
Department of Psychiatry
Deakin University
Geelong
Australia


Pamela E. Potter
Department of Pharmacology
Arizona College of Osteopathic Medicine Midwestern University
19555 Glendale
AZ
USA


Shishu Huang
State Key Laboratory of Oral Diseases
Sichuan University
Chengdu
China


Yan Li
Center for Tansport Phenomena
Energy Research Institute of Shandong Academy of Sciences
Jinan
Shandong, 250014
China


Yat-Fung Shea
Department of Medicine, LKS Faculty of Medicine
University of Hong Kong, Queen Mary Hospital
Hong Kong
China


You-Qiang Song
School of Biomedical Sciences
The University of Hong Kong, Pokfulam
Hong Kong
China
/
State Key Laboratory of Brain and Cognitive Sciences
The University of Hong Kong, Pokfulam
Hong Kong
China


Zhi-Gang Zhang
School of Biomedical Sciences
The University of Hong Kong, Pokfulam
Hong Kong
China




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