Frontiers in Clinical Drug Research-Anti Infectives

Volume 2

by

Atta-ur-Rahman

DOI: 10.2174/97816810815331160201
eISBN: 978-1-68108-153-3, 2016
ISBN: 978-1-68108-154-0
ISSN: 2452-3208 (Print)
ISSN: 2352-3212 (Online)



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Table of Contents

Preface

- Pp. i

Atta-ur-Rahman

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List of Contributors

- Pp. ii-iii (2)

Atta-ur-Rahman

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Recent Advances in Novel Antibacterial Development

- Pp. 3-61 (59)

Alberto J. Martín-Rodríguez, Héctor Quezada, Gabriel Becerril Aragón, César de la Fuente-Nuñez, Israel Castillo-Juarez, Toshinari Maeda, Valentina P. Salovarova, Thomas K. Wood and Rodolfo García- Contreras

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Antibiotic Resistance: Global Trends, Policies, and Novel Solutions

- Pp. 62-94 (33)

Balagangadhar R. Totapally Totapally and Andre Raszynski

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Drug Safety Approaches in Anti-Infective Drug Discovery and Development

- Pp. 95-136 (42)

Lucila I. Castro-Pastrana, Paola Serrano-Martínez and Lenin Domínguez- Ramírez

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Topical Antimicrobials: Classification and Performance

- Pp. 137-150 (14)

Daryl S. Paulson

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Identification of Nosocomial Pathogens and Antimicrobials Using Phenotypic Techniques

- Pp. 151-203 (53)

Marie Horká, Anna Kubesová, Dana Moravcová, Jiří Šalplachta, Jozef Šesták, Marie Tesařová and Filip Růžička

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Antimalarial Herbal Medicine: From Natural Products to Drug Molecules

- Pp. 204-232 (29)

Norma Rivera Fernández and Perla Y. López Camacho

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Drug Delivery Systems for Vaginal Infections

- Pp. 233-258 (26)

Sandra Borges, Joana Barbosa and Paula Teixeira

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Subject Index

- Pp. 259-268 (10)

Atta-ur-Rahman

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Preface

The second volume of Frontiers in Clinical Drug Research – Anti Infectives comprises seven chapters in various important fields including utilization of analytical techniques for identifying the nosocomial pathogens and antimicrobials, topical antimicrobials, anti-infective drug safety at global level, antimicrobial resistance and others.

In the first chapter, García-Contreras and colleagues discuss the current advancement in novel bacterial anti-infective drug development. They also discuss the in vitro and in vivo activity of anti-infective agents by analyzing their mechanisms of action and other recent advances in this field.

In the second chapter, Totapally and Raszynski have discussed the threat of antibiotic resistance at the global level, the causes involved in the development of antibiotic resistance and some solutions to overcome this huge problem.

Castro-Pastrana et al., in the third chapter discuss certain aspects of chemoinformatics, predictive clinical pharmacology and systems biology. They also discuss the utilization of preclinical models, in silico methods, translational biomarkers, genomics and the strategies of postmarketing surveillance during the development of anti-infective drugs for safety evaluation and risk management.

In chapter 4, Paulson discusses the topical antimicrobial products and describes their classification, mechanism of action, indications and the information regarding the products available in the market. Horka and colleagues mainly focus on nosocomial infections in chapter 5 and the analytical techniques helpful in the identification and estimation of levels of antibiotics and microorganisms in real samples.

In chapter 6, Fernández and Camacho present an overview of the use of natural product extracts, compounds and fractions that are known for their antimalarial activity. They also highlighted the strategies and challenges linked with contemporary antimalarial natural drug research, in the light of recent literature. In the last chapter, Teixera et al. discuss the antimicrobial agents that can be used for therapy in vaginal infections, different dosage forms and the risks and benefit associated with them. They also explain the new strategies and approaches applied in the vaginal drug delivery.

I would like to thanks all the authors for their excellent contributions. I am grateful to the outstanding efforts of the team of Bentham Science Publishers, comprising Dr. Faryal Sami and Mr. Shehzad Naqvi led by Mr. Mahmood Alam, Director Bentham Science Publishers.

Prof. Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Kings College
University of Cambridge
Cambridge
UK




Contributor(s):
Alberto J. Martín-Rodríguez
Institute for Bioorganic Chemistry “Antonio González”, Center for Biomedical Research of the Canary Islands (CIBICAN)
Department of Organic Chemistry, University of La Laguna, Tenerife
Spain and Oceanic Platform of the Canary Islands (PLOCAN)
Gran Canaria
Spain


Andre Raszynski
Nicklaus Children's Hospital, Miami, FL 33155.
Herbert Wertheim College of Medicine
Florida International University
Miami, FL.
USA


Anna Kubesová
Institute of Analytical Chemistry of the Czech Academy of Sciences
v. v. i., Veveří 97, 602 00 Brno
Czech Republic


Balagangadhar R. Totapally
Nicklaus Children's Hospital, Miami, FL 33155, USA.
Herbert Wertheim College of Medicine
Florida International University
Miami, FL,
USA


César de la Fuente-Nuñez
Synthetic Biology Group, MIT Synthetic Biology Center, Research Laboratory of Electronics, Department of Biological Engineering
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology
Cambridge, Massachusetts
USA
/
Broad Institute of MIT and Harvard University
Cambridge, Massachusetts
USA


Dana Moravcová
Institute of Analytical Chemistry of the Czech Academy of Sciences
v. v. i., Veveří 97, 602 00 Brno
Czech Republic


Daryl S. Paulson
BioScience Laboratories, Inc.,
Bozeman, Montana
USA


Filip Růžička
The Department of Microbiology, Faculty of Medicine, Masaryk University, Brno
Czech Republic
/
St. Anne's University Hospital, Brno, Pekařská 53, 65691 Brno
Czech Republic


Gabriel Becerril Aragón
Department of Physicochemical Biology
Faculty of Biology and Soil Studies
Irkutsk State University
K. Marx St.1 Irkutsk, 664003
Russia


Héctor Quezada
Laboratorio de Investigación en Inmunología y Proteómica
Hospital Infantil de México Federico Gómez
Mexico City
Mexico


Israel Castillo-Juarez
Colegio de Postgraduados
Campus Montecillo
Texcoco
Mexico


Jiří Šalplachta
Institute of Analytical Chemistry of the Czech Academy of Sciences
v. v. i., Veveří 97, 602 00 Brno
Czech Republic


Joana Barbosa
CBQF-Centro de Biotecnologia e Química Fina – Laboratório Associado
Escola Superior de Biotecnologia
Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital
Apartado 2511, 4202-401 Porto
Portugal


Jozef Šesták
Institute of Analytical Chemistry of the Czech Academy of Sciences
v. v. i., Veveří 97, 602 00 Brno
Czech Republic


Lenin Domínguez-Ramírez
Department of Chemical and Biological Sciences, School of Sciences
Universidad de las Américas Puebla,
Cholula
México


Lucila I. Castro-Pastrana
Department of Chemical and Biological Sciences, School of Sciences
Universidad de las Américas Puebla,
Cholula
México


Marie Horká
Institute of Analytical Chemistry of the Czech Academy of Sciences
v. v. i., Veveří 97, 602 00 Brno
Czech Republic


Marie Tesařová
Institute of Analytical Chemistry of the Czech Academy of Sciences
v. v. i., Veveří 97, 602 00 Brno
Czech Republic


Norma Rivera Fernández
Laboratory of Malariology, Department of Microbiology and Parasitology
Faculty of Medicine, National Autonomous University of Mexico
Mexico City, 04510
Mexico


Paola Serrano-Martínez
Department of Cell Biology
University Medical Center Groningen
University of Groningen, Groningen
The Netherlands


Paula Teixeira
CBQF-Centro de Biotecnologia e Química Fina – Laboratório Associado
Escola Superior de Biotecnologia
Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital
Apartado 2511, 4202-401 Porto
Portugal


Perla Y. López Camacho
Department of Natural Sciences,
Metropolitan Autonomous University
Cuajimalpa, Mexico City, 11850
Mexico


Rodolfo García-Contreras
Department of Microbiology and Parasitology
Faculty of Medicine, UNAM
Mexico City
Mexico


Sandra Borges
CBQF-Centro de Biotecnologia e Química Fina – Laboratório Associado
Escola Superior de Biotecnologia
Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital
Apartado 2511, 4202-401 Porto
Portugal


Thomas K. Wood
Department of Biochemistry and Molecular Biology, Pennsylvania State University, Pennsylvania
USA and Department of Chemical Engineering
Pennsylvania State University, Pennsylvania
USA


Toshinari Maeda
Department of Biological Functions Engineering
Kyushu Institute of Technology
Kitakyushu
Japan


Valentina T. Salovarova
Department of Physicochemical Biology
Faculty of Biology and Soil Studies
Irkutsk State University
K. Marx St.1 Irkutsk, 664003
Russia




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