Frontiers in Stem Cell and Regenerative Medicine Research

Volume 2

by

Atta-ur-Rahman , Shazia Anjum

DOI: 10.2174/97816810818301150201
eISBN: 978-1-68108-183-0, 2015
ISBN: 978-1-68108-184-7
ISSN: 2467-9593 (Print)
ISSN: 2352-7633 (Online)



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Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be pra...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur-Rahman and Shazia Anjum

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List of Contributors

- Pp. ii-iv (3)

Atta-ur-Rahman and Shazia Anjum

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Contribution of Stem Cells to Dental Tissue Regeneration: Isolation, Function, and Application

- Pp. 3-38 (36)

Atsushi Tomokiyo, Naohisa Wada and Hidefumi Maeda

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Epidermal Stem Cells and their Use in Regenerative Applications for Severe Cutaneous Injuries

- Pp. 39-62 (24)

Yella H. Martin and Anthony D. Metcalfe

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Biological and Therapeutic Implications of Cancer Stem Cells

- Pp. 63-101 (39)

Ruth M. Risueño, Amaia Etxabe and Josep Maria Cornet-Masana

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Role of Stem Cells in Heart Regeneration

- Pp. 102-115 (14)

Jianhua Xiong

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Differentiation Potential of Stem Cells into Ovarian Cells

- Pp. 116-156 (41)

Derek Toms, Paul W. Dyce and Julang Li

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Challenges and Opportunities in the Development of Induced Pluripotent Stem Cell Therapeutics

- Pp. 157-175 (19)

James A. Smith, Anna French, Hannah Hurley, Benjamin Davies, Sue Dopson, Paul Fairchild, Mackenna Roberts, Paul Riley, Brock Reeve, David Williams, Laurence Daheron, Kim Bure, Andrew Carr, Jeff Karp, Ivan Wal and David Brindley

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Cell Cycle and Cell Cycle Regulators in the Process of Development, Pluripotency, Differentiation, and Reprogramming

- Pp. 176-189 (14)

Xiao Qi Wang and Eric J. Stanbridge

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Effect of Microenvironment Modulation on Stem Cell Therapy for Peripheral Nerve Injury

- Pp. 190-224 (35)

Sufang Liu and Feng Tao

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Transplantation of Umbilical Cord Blood Cells for Patients with Neonatal Hypoxic-Ischemic Encephalopathy and Cerebral Palsy: From Preclinical Studies to Ongoing Clinical Trials

- Pp. 225-254 (30)

Pedro M. Pimentel-Coelho, Paulo H. Rosado-de-Castro, Fernanda Gubert and Rosalia Mendez-Otero

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Stem Cells for Treatment of Articular Cartilage Defects and Osteoarthritis

- Pp. 255-288 (34)

Shipin Zhang, Jun Sheng Wong, Fulya Ustunkan, Wern Cui Chu, Hee Hon Tan, Eng Hin Lee and Wei Seong Toh

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Subject Index

- Pp. 289-294 (6)

Atta-ur-Rahman and Shazia Anjum

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Preface

The second volume of ‘Frontiers in Stem Cell and Regenerative Medicine Research’ presents comprehensive reviews contributed by leading exponents in the exciting field of regenerative medicine.

Tomokiyo et al., the Japanese group of scientists have dealt with dental tissue regeneration and elaborated the potential of dental stem cells in clinical application in Chapter 1. Martin and Metcalfe in Chapter 2 have reviewed epidermal stem cells in the context of clinical application for patients with severe cutaneous injuries. This holds the potential to significantly improve wound healing in patients and positively influence clinical outcomes. Cancer stem cells (CSCs) are a subset of cells within a tumor having self-renewal and differentiation capacity. Risueño et al. in Chapter 3 present the biological and therapeutic implications of CSCs in preclinical and clinical studies.

Recent developments on stem cells in heart regeneration have stimulated studies directed towards potential clinical applications of this field. In Chapter 4, Xiong present an overview of the progress made towards unravelling the mechanisms underlying stem cell development and heart regeneration. In Chapter 5 of this volume Li et al. present the current state of research on the differentiation potential of stem cells into ovarian cells, their limitations and future prospects within the context of regenerative medicine. Smith et al. in Chapter 6 present the challenges and opportunities in the development of induced pluripotent stem cell therapeutics with special emphasis on immuno-compatibility and immune suppression issues.

The cell cycle machinery and its associated signaling pathways play important roles in regulation of stem cell properties. Wang and Stanbridge have summarized the current understanding of the role of the cell cycle and cell cycle regulators in the process of development, pluripotency, differentiation, and reprogramming in Chapter 7. Neural stem cells (NSCs) derived from the spinal cord have been shown to be useful in peripheral nerve regeneration. However, the stem cell therapy still exibits low efficiency. In Chapter 8 Liu and Tao discuss the effects of microenvironment on neural stem cell therapy for peripheral nerve injury and recent progress in this field.

A growing number of studies on the beneficial effects of umbilical cord blood cells (UCBCs) have improved our understanding regarding fundamental neuroprotective action of transplanted cells in animal models of HIE, intrauterine hypoxia and neonatal stroke. In Chapter 9, Pimentel-Coelho et al. discussed recent data from several clinical trials and case reports that have estimated the safety and feasibility of UCBCs therapy in newborns with hypoxic-ischemic encephalopathy (HIE) and in children with cerebral palsy.

In the last chapter, Toh et al. have reviewed the stem cell-based strategies that include direct intra-articular injection of mesenchymal stem cells and implantation of tissue-engineered cartilage grafts for treatment of cartilage defects and osteoarthritis.

We owe our special thanks to all the contributors for their valuable contributions to the second volume of this book. We are also grateful to the editorial staff of Bentham Science Publishers, particularly Dr. Faryal Sami, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their constant help and support.

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan

List of Contributors

Editor(s):
Atta-ur-Rahman
Kings College
University of Cambridge
Cambridge
UK


Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan




Contributor(s):
Anthony D. Metcalfe
Blond McIndoe Research Foundation
East Grinstead
West Sussex
United Kingdom

/
The Brighton Centre for Regenerative Medicine
University of Brighton
Brighton
East Sussex
United Kingdom



Amaia Etxabe
Josep Carreras Leukaemia Research Institute
Barcelona
Spain



Andrew Carr
The Oxford - UCL Centre for the Advancement of Sustainable Medical
Innovation (CASMI)
University of Oxford
Oxford
UK

/
Nuffield
Department of Orthopaedics
Rheumatology and Musculoskeletal Sciences

University of Oxford
Oxford
UK


Anna French
The Oxford - UCL Centre for the Advancement of Sustainable Medical
Innovation (CASMI)
University of Oxford
Oxford
UK



Atsushi Tomokiyo
Department of Endodontology and Operative Dentistry
Division of Oral Rehabilitation
Faculty of Dental Science
Kyushu University
Higashiku
Japan


Benjamin Davies
The Oxford - UCL Centre for the Advancement of Sustainable Medical
Innovation (CASMI)
University of Oxford
Oxford
UK

/
Nuffield
Department of Orthopaedics
Rheumatology and Musculoskeletal Sciences

University of Oxford
Oxford
UK


Brock Reeve
Harvard Stem Cell Institute
Harvard University
Cambridge
MA
USA



David Brindley
The Oxford - UCL Centre for the Advancement of Sustainable Medical
Innovation (CASMI)
University of Oxford
Oxford
UK

/
Nuffield
Department of Orthopaedics
Rheumatology and Musculoskeletal Sciences
University of Oxford
Oxford
UK
/
Centre for Behavioural Medicine
University College London
London
UK

/
Harvard Stem Cell Institute
Harvard University
Cambridge
MA
USA

/
Stanford-UCSF
FDA Centre for Regulatory Science and Innovation
Saïd Business School
University of Oxford
Oxford
UK


David Williams
Centre for Biological Engineering
Wolfson School of Mechanical and Manufacturing Engineering
Loughborough University
Loughborough
LE11 3TU
UK


Derek Toms
Department of Animal Biosciences
University of Guelph
Guelph
Ontario
Canada

/
Department of Comparative Biology and Experimental Medicine
University of Calgary
Calgary
Alberta
Canada



Eng Hin Lee
Department of Orthopaedic Surgery
Yong Loo Lin School of Medicine
National University of Singapore
Singapore

/
Tissue Engineering Program
Life Sciences Institute
National University of Singapore
Singapore



Eric J. Stanbridge
Department of Microbiology and Molecular Genetics
University of California
Irvine School of Medicine
California
USA



Feng Tao
Department of Biomedical Sciences
Texas A&M University Baylor
College of Dentistry
3302 Gaston Avenue
Dallas
Texas
USA


Fernanda Gubert
Instituto de Biofísica Carlos Chagas Filho
Universidade Federal do Rio Janeiro
Rio de Janeiro
Brazil



Fulya Ustunkan
Department of Orthopaedic Surgery
Yong Loo Lin School of Medicine
National University of Singapore
Singapore



Hannah Hurley
The Oxford - UCL Centre for the Advancement of Sustainable Medical
Innovation (CASMI)
University of Oxford
Oxford
UK

/
Nuffield
Department of Orthopaedics
Rheumatology and Musculoskeletal Sciences
University of Oxford
Oxford
UK


Hee Hon Tan
Faculty of Dentistry
National University of Singapore
Singapore



Hidefumi Maeda
Department of Endodontology and Operative Dentistry
Division of Oral Rehabilitation
Faculty of Dental Science
Kyushu University
Higashiku
Japan


Ivan Wall
Department of Biochemical Engineering
University College London
London
WC1H 0AH
UK

/
Department of Nanobiomedical Science and
BK21 Plus NBM Global Research Center of Regenerative Medicine
Dankook University
Cheonan 330-714
Republic of Korea

/
Institute of Tissue Regeneration Engineering
Dankook University Graduate School
Cheonan 330-714
Republic of Korea



James A. Smith
The Oxford - UCL Centre for the Advancement of Sustainable Medical
Innovation (CASMI)
University of Oxford
Oxford
UK

/
Nuffield
Department of Orthopaedics
Rheumatology and Musculoskeletal Sciences
University of Oxford
Oxford
UK


Jeff Karp
Harvard Stem Cell Institute
Harvard University
Cambridge
MA
USA

/
Division of Biomedical Engineering
Brigham and Women's Hospital
Harvard Medical School
Boston
MA
USA
/
Harvard-MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology
Cambridge
MA
USA



Jianhua Xiong
Center for Molecular Medicine
National Heart, Lung and Blood Institute
National Institutes of Health
Bethesda
Maryland 20892
USA


Josep Maria Cornet-Masana
Josep Carreras Leukaemia Research Institute
Barcelona
Spain



Julang Li
Department of Animal Biosciences
University of Guelph
Guelph
Ontario
Canada



Jun Sheng Wong
Faculty of Dentistry
National University of Singapore
Singapore



Kim Bure
The Oxford - UCL
Centre for the Advancement of Sustainable Medical Innovation (CASMI)
University of Oxford
Oxford
UK

/
Sartorius
Stedim
Göttingen
Germany



Laurence Daheron
Harvard Stem Cell Institute
Harvard University
Cambridge
MA
USA



Mackenna Roberts
The Oxford - UCL Centre for the Advancement of Sustainable Medical
Innovation (CASMI)
University of Oxford
Oxford
UK



Naohisa Wada
Division of General Oral Clinic
Kyushu University Hospital
Higashi-ku
Japan



Paul Fairchild
Sir William Dunn School of Pathology
University of Oxford
Oxford
UK



Paul Riley
Department of Physiology
Anatomy and Genetics
University of Oxford
Oxford
UK



Paul W. Dyce
Department of Animal Biosciences
University of Guelph
Guelph
Ontario
Canada

/
Department of Animal Sciences
Auburn University
Auburn
Alabama
USA



Paulo H. Rosado-de-Castro
Instituto de Ciências Biomédicas
Universidade Federal do Rio de Janeiro
Rio de Janeiro
Brazil



Pedro M. Pimentel-Coelho
Instituto de Biofísica Carlos Chagas Filho
Universidade Federal do Rio Janeiro
Rio de Janeiro
Brazil



Rosalia Mendez-Otero
Instituto de Biofísica Carlos Chagas Filho
Universidade Federal do Rio Janeiro
Rio de Janeiro
Brazil



Ruth M. Risueño
Josep Carreras Leukaemia Research Institute
Barcelona
Spain



Shipin Zhang
Faculty of Dentistry
National University of Singapore
Singapore



Sue Dopson
Saïd Business School
University of Oxford
Oxford
UK



Sufang Liu
Department of Physiology
Zhengzhou University School of Medicine
Zhengzhou
Henan Province
China



Wei Seong Toh
Faculty of Dentistry
National University of Singapore
Singapore

/
Tissue Engineering Program
Life Sciences Institute
National University of Singapore
Singapore



Wern Cui Chu
Faculty of Dentistry
National University of Singapore
Singapore



Xiao Qi Wang
Department of Surgery
The University of Hong Kong
Hong Kong



Y.H. Martin
Blond McIndoe Research Foundation
East Grinstead
West Sussex
United Kingdom

/
The Brighton Centre for Regenerative Medicine
University of Brighton
Brighton
East Sussex
United Kingdom





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