Unfolding the Biopolymer Landscape

Book Series: Frontiers in Biomaterials

Volume 2

by

Viness Pillay, Yahya E. Choonara, Pradeep Kumar

DOI: 10.2174/97816810819531160201
eISBN: 978-1-68108-195-3, 2016
ISBN: 978-1-68108-196-0
ISSN: 2468-0168 (Print)
ISSN: 2352-3921 (Online)



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Indexed in: EBSCO.

The need for the development of biomaterials as scaffold for tissue regeneration is driven by the increasing demands for materials tha...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Dhanjay Jhurry

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Preface

- Pp. ii

Viness Pillay, Yahya E. Choonara and Pradeep Kumar

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List of Contributors

- Pp. iii-v (3)

Viness Pillay, Yahya E. Choonara and Pradeep Kumar

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Cationic Polymers for Biotechnological Applications

- Pp. 3-27 (25)

Roxana V. Alasino, Karina L. Bierbrauer, Dante M. Beltramo, Silvia G. Correa and Ismael D. Bianco

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Collagen Substrates for Soft Tissue Engineering

- Pp. 28-53 (26)

Edward Suesca, Alejandro Sosnik and Marta R. Fontanilla

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Gums and Mucilages Based Mucoadhesive Biopolymers

- Pp. 54-75 (22)

Inderbir Singh and Pradeep Kumar

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Natural Polymers for Ophthalmic Drug Delivery

- Pp. 76-91 (16)

Anjali Hirani, Yong W. Lee, Vijaykumar B. Sutariya and Yashwant Pathak

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Customized Shape-Memory Biopolymers

- Pp. 92-123 (32)

Lisa C. du Toit, Thashree Marimuthu, Pradeep Kumar, Yahya E. Choonara and Viness Pillay

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Biotextiles for Tissue Engineering

- Pp. 124-142 (19)

Navdeep Grover and Lomas K. Tomar

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Hybrid Semi-Synthetic Polyhydroxy Acid Based- Biomaterials

- Pp. 143-179 (37)

Swati Jain, Sruti Chattopadhyay and Harpal Singh

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Microbial Exopolysaccharides for Biomedical Applications

- Pp. 180-238 (59)

Silvia Vasiliu, Stefania Racovita, Maria-Andreea Lungan, Jacques Desbrieres and Marcel Popa

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Bio-Interfacial Properties of Environmentally Responsive Biomaterials

- Pp. 239-265 (27)

Charu Tyagi, Lomas K. Tomar and Divya Bijukumar

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Bio & Polymeric Materials Mimicking the Extra- Cellular Microenvironment

- Pp. 266-325 (60)

Riaz A. Khan

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Biopolymers in Non-Aqueous Emulsions for Food and Pharmaceutical Applications

- Pp. 326-352 (27)

Marcelo R. Ceballos, Dante M. Beltramo and Ismael D. Bianco

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Biopolymers for Neurotherapeutic Interventions

- Pp. 353-380 (28)

Valence M.K. Ndesendo

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Porous and Non-Porous Metallic Biomaterials

- Pp. 381-408 (28)

Oluwatoyin Ayotomilola Adeleke

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Derivatized Polysaccharides: A Potential in Micro/Nanoparticulate Based Drug Delivery

- Pp. 409-451 (43)

Vikas Rana, Sunil Kamboj and Kuldeep Singh

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Subject Index

- Pp. 452-458 (7)

Viness Pillay, Yahya E. Choonara and Pradeep Kumar

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Foreword

This eBook provides an expert and up-to-date overview of the use of biopolymers in the design of smart therapeutic delivery systems, tissue-engineered scaffolds, implants and devices. It also covers future trends in the design and application of biopolymers and their overall potential benefits. The versatility of biopolymer technology and modification is channelled towards the development of advanced drug delivery systems for the treatment of various diseases as well as the elaboration of nanoscale structures for scaffolding. The various chapters of this eBook with contributions from polymer chemists, pharmaceutical scientists, chemists, biomedical and chemical engineers and other allied disciplines show that multi-disciplinarity is key for spanning the frontiers in biopolymer synthesis, modification and applications. The presentation of state-ofthe- art research in the biopolymer area should be most helpful not only to researchers in the field but also to graduate students. Finally, the consolidation of ideas within this eBook, evident through the sterling credentials of the Editor Prof Viness Pillay, generates a unique viewpoint for the conceptualisation of novel biopolymeric systems in future.

Dhanjay Jhurry
National Research Chair
Centre for Biomedical and Biomaterials Research (CBBR)
MSIRI Building
Réduit, Mauritius


Preface

The biopolymer landscape is undergoing a revolution and illuminates the propensity of certain multifunctional biomaterials to change the way biopolymers are synthesized and applied for the design of scaffolds in tissue engineering, controlling the spatial and temporal release of bioactives into the human body as well as to modulate the physicochemical and physicomechanical properties of therapeutic systems for enhanced form and function. For example at the Wits Advanced Drug Delivery Platform (WADDP) (http://www.wits.ac.za/waddp) we focus on specialized biopolymers that allow us to design therapeutic systems that can perform functions outside their range of conventional capability and into the blue skies realm, including 3D printability. The mechanized uniqueness of biopolymers is embodied not only in their macroscopic structural changes, but also in their ability to respond to varying stimuli, reversibly change their shape or even behave as in vivo tissue or organ surrogates. Such biopolymers have been applied in a vast array of biomedical applications that include stimuli-sensitive bioactive delivery systems, intelligent medical and surgical devices, tissue engineering, or implants for minimally invasive surgery. In this eBook, we provide a topographical view of the tortuous biopolymer landscape and elaborate on the fundamental molecular mechanisms and physical dynamics of polymer behavior that bring about their advanced function. Furthermore, we highlight the diverse stimuli that instigate biopolymer function and discuss those that have undergone modification, functionalization and customization for specialized biomedical applications. We would like to thank the experts who have made immense contributions to the various Chapters within this eBook and have emphasized the fact that certainly the biopolymer landscape is far from flat. The future is exciting.

Viness Pillay
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
School of Therapeutic Sciences, Faculty of Health Sciences
University of the Witwatersrand. Johannesburg
7 York Road, Parktown, 2193
South Africa

Yahya E. Choonara
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
School of Therapeutic Sciences, Faculty of Health Sciences
University of the Witwatersrand. Johannesburg
7 York Road, Parktown, 2193
South Africa
&

Pradeep Kumar
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
Faculty of Health Sciences
University of the Witwatersrand. Johannesburg
7 York Road, Parktown, 2193
South Africa


List of Contributors

Editor(s):
Viness Pillay
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
School of Therapeutic Sciences, Faculty of Health Sciences
University of the Witwatersrand, Johannesburg
7 York Road, Parktown, 2193
South Africa


Yahya E. Choonara
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
Faculty of Health Sciences
University of the Witwatersrand, Johannesburg
7 York Road, Parktown, 2193
South Africa


Pradeep Kumar
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
Faculty of Health Sciences
University of the Witwatersrand, Johannesburg
7 York Road, Parktown, 2193
South Africa




Contributor(s):
Alejandro Sosnik
Group of Pharmaceutical Nanomaterials Science
Department of Materials Science and Engineering
Technion-Israel Institute of Technology
Haifa
Israel


Anjali Hirani
Department of Pharmaceutical Sciences, USF College of Pharmacy
University of South Florida
Tampa, FL 33612

/
School of Biomedical Engineering and Sciences
Virginia Tech-Wake Forest University
Blacksburg
VA 24061



Charu Tyagi
University of the Witwatersrand, Faculty of Health Sciences
Department of Pharmacy and Pharmacology
7 York Road, Parktown 2193
Johannesburg
South Africa
/
V.S.P.G.(P.G) College
C.C.S University
Meerut
U.P., 250004
India


Dante M. Beltramo
Centro de Excelencia en Productos y Procesos de Córdoba (CEPROCOR)
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and Facultad de Ciencias Químicas
Universidad Católica de Córdoba
Argentina


Divya Bijukumar
University of the Witwatersrand, Faculty of Health Sciences
Department of Pharmacy and Pharmacology
7 York Road, Parktown 2193
Johannesburg
South Africa


Edward Suesca
Tissue Engineering Group, Department of Pharmacy
Universidad Nacional de Colombia
Bogotá
Colombia


Harpal Singh
Indian Institute of Technology Delhi (IIT D), Hauz Khas
New Delhi
India


Inderbir Singh
Department of Pharmaceutics, Chitkara College of Pharmacy
Chitkara University, Chandigarh-Patiala Highway
Chandigarh-Patiala Highway, Rajpura-140401
Patiala, Punjab
India


Ismael D. Bianco
Centro de Excelencia en Productos y Procesos de Córdoba (CEPROCOR)
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and Facultad de Ciencias Químicas
Universidad Católica de Córdoba
Argentina


Jacques Desbrieres
Pau and Pays de l’Adour University (UPPA), Institut des Sciences Analytiques et de Physico-Chimie pour l’Environnement et les Materiaux (IPREM/EPCP)
UMR CNRS 5254, Helioparc Pau Pyrenees, 2, av. President Angot
64053 Pau Cedex 09
France


Karina L. Bierbrauer
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Argentina


Kuldeep Singh
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research
Punjabi University
Punjabi University
India-147002


Lisa C. du Toit
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
School of Therapeutic Sciences, Faculty of Health Sciences
University of the Witwatersrand, Johannesburg
7 York Road, Parktown, 2193
South Africa


Lomas K. Tomar
University of the Witwatersrand, Faculty of Health Sciences
Department of Pharmacy and Pharmacology
7 York Road, Parktown, 2193
Johannesburg, Gauteng
South Africa


Marcel Popa
“Gheorghe Asachi” Technical University of Iasi,
Faculty of Chemical Engineering and Environmental Protection Department of Natural and Synthetic Polymers
rof. Dr. Docent Dimitrie Mangeron Street, No. 73, 700050
Iasi
Romania


Marcelo R. Ceballos
Centro de Excelencia en Productos y Procesos de Córdoba (CEPROCOR)
Argentina


Maria-Andreea Lungan
“Gheorghe Asachi” Technical University of Iasi,
Faculty of Chemical Engineering and Environmental Protection Department of Natural and Synthetic Polymers
rof. Dr. Docent Dimitrie Mangeron Street, No. 73, 700050
Iasi
Romania


Marta R. Fontanilla
Tissue Engineering Group, Department of Pharmacy, Universidad Nacional de Colombia
Bogotá
Colombia


Navdeep Grover
Department of Chemical and Biological Engineering
University of Colorado Boulder
3415 Colorado Avenue, Boulder
Colorado
USA


Oluwatoyin Ayotomilola Adeleke
Council for Scientific and Industrial Research
Meraka Institute, Centre for High Performance Computing
627 Meiring Naudé Road
Pretoria 0001
South Africa


Pradeep Kumar
Pradeep Kumar Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology
School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand
Johannesburg, 7 York Road, Parktown, 2193
South Africa


Riaz A. Khan
Department of Medicinal Chemistry, College of Pharmacy, Qassim University
Qassim 51452, KSA and Department of Chemistry, MRIU, Aravali Hills
National Capital Region, Faridabad
HR 121001
India


Roxana V. Alasino
Centro de Excelencia en Productos y Procesos de Córdoba (CEPROCOR)
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and Facultad de Ciencias Químicas
Universidad Católica de Córdoba
Argentina


Silvia G. Correa
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and Facultad de Ciencias Químicas
Universidad Nacional de Córdoba
Argentina


Silvia Vasiliu
“Petru Poni” Institute of Macromolecular Chemistry
University of ArakGr. Ghica Voda Alley No. 41A, 700487
Iasi
Romania


Sruti Chattopadhyay
Indian Institute of Technology Delhi (IIT D), Hauz Khas
New Delhi
India


Stefania Racovita
“Petru Poni” Institute of Macromolecular Chemistry
University of ArakGr. Ghica Voda Alley No. 41A, 700487
Iasi
Romania


Sunil Kamboj
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research
Punjabi University
Patiala, Punjab
India-147002


Swati Jain
Amity Institute of Nanotechnology
Amity University
Sec. 125, Noida
Uttar Pradesh
India


Thashree Marimuthu
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
School of Therapeutic Sciences, Faculty of Health Sciences
University of the Witwatersrand, Johannesburg
7 York Road, Parktown, 2193
South Africa


Valence M.K. Ndesendo
Department of Pharmaceutics & Formulation Sciences, School of Pharmacy & Pharmaceutical Sciences
St. John’s University of Tanzania
Dodoma
Tanzania


Vijaykumar B. Sutariya
Department of Pharmaceutical Sciences, USF College of Pharmacy
University of South Florida
Tampa, FL 33612
USA


Vikas Rana
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research
Punjabi University
Patiala, Punjab
India-147002


Viness Pillay
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
School of Therapeutic Sciences, Faculty of Health Sciences
University of the Witwatersrand, Johannesburg
7 York Road, Parktown, 2193
South Africa


Yahya E. Choonara
Wits Advanced Drug Delivery Platform Research Unit
Department of Pharmacy and Pharmacology
School of Therapeutic Sciences, Faculty of Health Sciences
University of the Witwatersrand, Johannesburg
7 York Road, Parktown, 2193
South Africa


Yashwant Pathak
Department of Pharmaceutical Sciences, USF College of Pharmacy
University of South Florida
Tampa, FL 33612
USA
/
School of Biomedical Engineering and Sciences
Virginia Tech-Wake Forest University
Blacksburg, VA 24061
USA




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