Molecular and Cellular Biology of Pathogenic Trypanosomatids

Book Series: Frontiers in Parasitology

Volume 1

by

Marcelo Santos da Silva, Maria Isabel N. Cano

DOI: 10.2174/97816810840531170101
eISBN: 978-1-68108-405-3, 2017
ISBN: 978-1-68108-406-0
ISSN: 2542-4211 (Print)
ISSN: 2542-422X (Online)





Every year millions of people living in tropical areas across the globe, are affected by trypanosomatids – the parasites causing Chaga...[view complete introduction]

Recombinant Vaccines Against Pathogenic Trypanosomatids

- Pp. 531-585 (55)

Priscila Martins Andrade Denapoli, Alba Marina Gimenez and Maurício Martins Rodrigues

Abstract

The Leishmania spp, Trypanosoma cruzi and Trypanosoma brucei spp are the causative agents of tropical infections, and over 20 million people worldwide suffer from these neglected diseases. During the last century, vaccine development has had an undeniable impact on public health and may offer some alternatives for the control of parasitic diseases. Immune protection against experimental infection with these parasites has been studied and many types of immunogens have been used. Use of new technologies has allowed the development of recombinant proteins and DNA-based vaccines against those protozoans, aiming to generate both humoral and cellular protective responses. A large amount of data have been obtained from preclinical model systems which gave us promising results. The main challenge at the present is to translate what has been succeeded in these models into efficient human vaccines. The objective of this review is to summarize the efforts of the science community about the development of recombinant vaccines against trypanosomatids.

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