Frontiers in Stem Cell and Regenerative Medicine Research

Volume 4

by

Atta-ur-Rahman , Shazia Anjum

DOI: 10.2174/97816810843501170401
eISBN: 978-1-68108-435-0, 2017
ISBN: 978-1-68108-436-7
ISSN: 2467-9593 (Print)
ISSN: 2352-7633 (Online)



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Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be pra...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur-Rahman and Shazia Anjum

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List of Contributors

- Pp. ii

Atta-ur-Rahman and Shazia Anjum

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Retrodifferentiation: From Concept to Bedside Stem Cell Therapy

- Pp. 3-35 (33)

Ilham Saleh Abuljadayel

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The Mesendoderm: A Wellspring of Cell Lineages for Regenerative Medicine

- Pp. 36-100 (65)

Badwi B. Boumelhem, Stephen J. Assinder, Christoph Hammans, Marietta P. Tanudisastro, Damien T. M. Le, Kurt W. L. Brigden and Stuart T. Fraser

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Hematopoiesis and Regenerative Medicine

- Pp. 101-169 (69)

Chanukya K. Colonne, Veronica I. Antas, Jia Hao Yeo, Henry Williams, Chelsea Pilgrim and Stuart T. Fraser

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Cell-based Therapy in Veterinary Medicine

- Pp. 170-233 (64)

Chad Maki, Thomas Ramos and Fariborz Izadyar

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From Trials to Therapeutics: are Mesenchymal Stem Cells Promising in Cellular Therapy?

- Pp. 234-262 (29)

Ganapathi M. Bhat, Pooja Shahapurkar and Rasika G. Bhat

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Subject Index

- Pp. 263-274 (12)

Atta-ur-Rahman and Shazia Anjum

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Preface

There continues to be tremendous progress in the field of stem cell and regenerative medicine research. The developments promise to change the face of medicine. This 4th volume of ‘Frontiers in Stem Cell and Regenerative Medicine Research’ should be of considerable interest to the readers as it presents state-of-the art reviews written by renowned experts in this fast moving field.

Ilham Saleh Abduljadayel presented a comprehensive review in chapter 1 on epimorphic regeneration and retrodifferentiation. Both processes have the capacity to recreate and reconstruct tissue with precise positional integration of cells in such a way that will enable healing without scars. In chapter 2 Fraser et al. extensively reviewed the unique genetic programmes that lead to mesendoderm formation and the pathways leading to mesoderm and endoderm specification. They also present examples where mature cell types from both germ layers interact to support their mutual development. These programmes are being employed to direct the differentiation of pluripotent cells in vitro into mesendoderm derived cells and tissues. Fraser et al. also reviewed the role of stem, progenitor and supportive cells within the hematopoietic tissues as essential elements of regenerative medicine in chapter 3.

Cell-based therapy is an emerging field in veterinary medicine that has been used for developing new therapies for degenerative diseases. In chapter 4 Izadyar et al. described different cell based therapies, their risks and benefits and their possible therapeutic use for veterinary medical applications. Mesenchymal stem cells (MSCs) are the most favored cellular candidates for regenerative therapeutics. Bhat et al. discussed how MSCs contribute to therapeutic efficiency include facilitating secretion of bioactive factors, induction of cellular recruitment and retention of progenitor faculties in the last chapter.

Knowledge of stem cell and regenerative medicine research continues to move ahead on many fronts. We hope that the readers will enjoy reading about the latest and stimulating development in this hot area in the 4th volume of this series.

We are pleased to place on record our heartfelt thanks to all the authors for their contributions. We are also grateful to the editorial staff of Bentham Science Publishers, particularly Dr. Faryal Sami, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their constant support and great help.

Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

&

Dr. Shazia Anjum
Department of Chemistry
The Islamia University of Bahawalpur
Pakistan

List of Contributors

Editor(s):
Atta-ur-Rahman
Kings College
University of Cambridge
Cambridge
UK


Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan




Contributor(s):
Badwi B. Boumelhem
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Chad Maki
VetCell Therapeutics
2917 Daimler Street
Santa Ana CA 92705
USA


Chanukya K. Colonne
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Chelsea Pilgrim
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Christoph Hammans
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Damien T. M. Le
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Fariborz Izadyar
VetCell Therapeutics
2917 Daimler Street
Santa Ana CA 92705
USA


Ganapathi. Bhat. M.
Jaslok Hospital and Research centre, 15, Dr. G. Deshmukh Marg
Mumbai 400026
Maharashtra
India


Henry Williams
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Ilham Saleh Abuljadayel
TriStem UK Limited
571 Finchley Road, Unit 320
London
England


Jia Hao Yeo
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Kurt W. L. Brigden
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Marietta P. Tanudisastro
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Pooja Shahapurkar
Jaslok Hospital and Research centre, 15, Dr. G. Deshmukh Marg
Mumbai 400026
Maharashtra
India


Rasika G. Bhat.
Department of Medical Genetics
College of Nursing, Bombay Hospital
Mumbai 400026
Maharashtra
India


Stephen J. Assinder
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Stuart T. Fraser
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia
/
Discipline of Anatomy & Histology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia


Thomas Ramos
VetCell Therapeutics
2917 Daimler Street
Santa Ana CA 92705
USA


Veronica I. Antas
Discipline of Physiology, School of Medical Science
University of Sydney
Camperdown
New South Wales
Australia




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