Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates

by

Karoly Tihanyi , Monika Vastag

DOI: 10.2174/97816080512051110101
eISBN: 978-1-60805-120-5, 2011
ISBN: 978-1-60805-619-4



Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, Scopus, Chemical Abstracts, EBSCO.

This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability...[view complete introduction]
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Recent Advances in ADME Predictions

- Pp. 3-32 (30)

Laszlo Molnar and Gyorgy M. Keseru

Abstract

The basic objective of medicinal chemistry is to deliver not only potent in vitro chemicals, but also, more importantly, drug candidates that can be progressed to clinical trials and that will eventually reach the market. This is a long and winding road – one that is often tricky to follow and that sometimes reaches a dead end. Over the past few decades, the pharmaceutical industry has learned that ADME and related parameters are of pre-eminent importance in selecting a successful candidate. This chapter briefly discusses the most important physico-chemical and other more complex ADME parameters, while focusing on in silico prediction. Historical approaches are mentioned, but, as the title suggests, the emphasis is on recent advances. The authors’ intention is to help medicinal chemists to achieve their goal of identifying new therapeutic options for human diseases.

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