Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates

by

Karoly Tihanyi , Monika Vastag

DOI: 10.2174/97816080512051110101
eISBN: 978-1-60805-120-5, 2011
ISBN: 978-1-60805-619-4



Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, Scopus, Chemical Abstracts, EBSCO.

This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability...[view complete introduction]
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Physicochemical Characterization of NCEs in Early Stage Drug Discovery

- Pp. 33-51 (19)

Gyorgy T. Balogh

Abstract

In the last two decades, the role of physicochemical parameters has come to the forefront of early stage drug discovery. The primary driver behind this revolution is the fact that the pharmacokinetic properties of hit and lead compounds have become worse and worse. In this chapter, the theoretical background and measurement techniques for the more important physicochemical parameters are introduced from the perspective of the ADME/T processes. Finally, during the last decade a number of significant ADME/T-physicochemical-based structure relationships have been shown to be relevant.

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