Chemoinformatics: Directions Toward Combating Neglected Diseases


Teodorico C. Ramalho

DOI: 10.2174/97816080518301120101
eISBN: 978-1-60805-183-0, 2012
ISBN: 978-1-60805-502-9

Indexed in: Scopus, EBSCO.

Low-income populations in developing regions of Africa, Asia and the Americas have been particularly injured by a group of tropical in...[view complete introduction]
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New Approaches to the Development of Anti-Protozoan Vaccine and Drug Candidates: A Review of Patents

- Pp. 3-32 (30)

Elaine F.F. da Cunha, Teodorico C. Ramalho, Daiana T. Mancini and Matheus P. Freitas


Protozoan infections are parasitic diseases that affect hundreds and millions of people worldwide, but have been largely neglected for drug development because they affect poor people in poor regions of the world. Most of the current drugs used to treat these diseases are decades old and have many limitations, including the emergence of drug resistance. This review will focus on the most recent developments, from 2001 to 2008, published in the field of patents and publications, paying particular attention to promising compounds acting against trypanosomiasis, leishmaniasis, malaria, toxoplasmosis, amebiasis, giardiasis, balantidiasis and pneumocystosis, their chemistry and biological evaluation, and to new chemical and pharmaceutical processes.

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