Sialobiology: Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease

by

Joe Tiralongo, Ivan Martinez-Duncker

DOI: 10.2174/97816080538651130101
eISBN: 978-1-60805-386-5, 2013
ISBN: 978-1-60805-067-3



Indexed in: Scopus, EBSCO.

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The im...[view complete introduction]
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Mammalian Sialidases

- Pp. 188-208 (21)

Tadashi Suzuki and Kazunori Yamaguchi

Abstract

Sialic acids (Sia) play major roles in glycan-mediated recognition/interaction processes, which are mediated by various intrinsic and extrinsic sialic acid-binding proteins. Cells therefore require fine-tuned mechanisms to regulate cell-surface expression of sialoglycoconjugates. In mammalian cells, there are 4 distinct sialidases, termed NEU1, NEU2, NEU3 and NEU4, involved in the removal of sialic acid residues from glycoconjugates; they play pivotal roles in diverse biological processes. In this chapter we summarize our current knowledge on mammalian sialidases.

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