Sialobiology: Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease

by

Joe Tiralongo, Ivan Martinez-Duncker

DOI: 10.2174/97816080538651130101
eISBN: 978-1-60805-386-5, 2013
ISBN: 978-1-60805-067-3



Indexed in: Scopus, EBSCO.

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The im...[view complete introduction]
US $
Buy Personal eBook
89
Order Library eBook
356
Order Printed Copy
*206
Order PDF + Printed Copy (Special Offer)
*250

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology
Download Flyer

Sialic Acids and Cancer

- Pp. 381-403 (23)

Alexandre S. Stephens, Christopher J. Day and Joe Tiralongo

Abstract

Altered cell surface sialylation is a hallmark of cancer. Investigation of clinical samples, cell lines and animal models has revealed associations between aberrant sialylation and cancer progression. Total serum and lipid bound sialic acid (Sia) levels are elevated in many types of cancer displaying a positive correlation with cancer stage and grade. The expression of α2-3 and α2-6 linked Sia and the levels of sialylated structures sialyl-Tn, sialyl Lewis a (SLea) and sialyl Lewis x (SLex) are also elevated in cancer cases. The metastatic potential of cancer cells is positively correlated to the levels of terminal galactose and N-acetylgalactosamine sialylation and the activities and mRNA expression levels of sialyltransferases and sialidases/neuraminidases are also significantly altered in cancer. The potential mechanisms via which altered sialylation is contributed to the progression of cancer have been studied. Increased Sia expression on the surface of cancer cells can enhance cell-cell repulsion and such an effect can potentially promote the dispersion of cells from primary tumor encouraging metastasis. Enhanced invasion, migration and altered binding to extracellular matrix, which are cell characteristics associated with metastatic behaviour, have also been linked to changes in sialylation. Increased resistance to apoptosis which can confer a growth advantage and the elevated expression of selectin ligands, SLea and SLex, can facilitate the transport of cancer cells throughout the blood stream and participate in the docking of cancer cells to the vascular endothelium at distant sites have also been observed in cancer cells displaying aberrant sialylation.

Purchase Chapter  Book Details

Advertisement


Webmaster Contact: info@benthamscience.net Copyright © 2019 Bentham Science