Frontiers in RNAi

Volume 1

by

Ralph A. Tripp, Jon M. Karpilow

DOI: 10.2174/97816080594091140101
eISBN: 978-1-60805-940-9, 2014
ISBN: 978-1-60805-941-6
ISSN: 2352-8400 (Print)



Indexed in: EBSCO.

RNA Interference (RNAi) arrived in the scientific community just over a decade ago, and has since blossomed with new connections being...[view complete introduction]
US $
Open Access
(Free to download)
0
Click here!
Order Printed Copy
*97

*(Excluding Mailing and Handling)
Download Flyer

RNAi for Viral Disease Control

- Pp. 79-106 (28)

Cameron R. Stewart, S. Mark Tompkins, Kristie A. Jenkins, Leonard H. Izzard, John Stambas, Andrew G. Bean, Mark L. Tizard, Timothy J. Doran and John W. Lowenthal

Abstract

Zoonotic viruses emerging from wildlife and domesticated animals pose a serious threat to human and animal health and are recognised as the most likely source of the next pandemic. Containment of emerging infectious disease (EID) outbreaks is often difficult due to their unpredictability and the absence of effective control measures, such as vaccines, therapies and diagnostics. RNA interference (RNAi) provides a novel and effective therapeutic strategy to combat infectious diseases through modulation of pathogen and/or host gene expression. In this chapter we discuss the applications of RNAi to combat EIDs. We discuss how RNAi has furthered understanding of virus lifecycles by making possible genome-wide functional genomics studies to discover host functions that are essential for virus replication, and in the process, identify new targets for antiviral therapies. We also discuss the advantages and hurdles associated with the use of RNAi as antiviral therapeutics, in addition to the engineering of disease-resistant livestock using RNAi to protect both humans and animals from EIDs.

Download Free  Book Details

Advertisement


Webmaster Contact: info@benthamscience.org Copyright © 2017 Bentham Science