Frontiers in Medicinal Chemistry

Volume 7


Atta-ur-Rahman , M. Iqbal Choudhary , Jizhou Wang, Allen B. Reitz

DOI: 10.2174/97816080597061150701
eISBN: 978-1-60805-970-6, 2015
ISBN: 978-1-60805-971-3
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)

Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

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Therapeutic Approaches to Liver Fibrosis

- Pp. 336-384 (49)

Enrico Maria Zardi


The advancements in the molecular pathogenesis and a deeper comprehension of cellular mechanisms of liver fibrosis promise to give new therapeutic approaches to the management of this disease in the future. </p><p> Apoptosis, cytokines, oxidants, and inflammosomes play a complex role in favouring or delaying the onset of liver fibrosis; sustained hepatic stellate cell activation and transformation, without forgetting the role of hepatocytes and other complex molecular and cellular mechanisms, are the direction that guides to fibrosis. </p><p> Therefore, in this review, after considering the causes of the development of fibrosis as well as the interrelation between molecular and cellular profibrotic mechanisms, we will focus on the part played in counteracting both of these actions by some anti-oxidants and anti-fibrotic molecules such as cytokines, prostacyclin and others. </p><p> Further validation in animal studies and confirmation in clinical trials are requested. Some data that are already available from in vitro and animal studies demonstrating the effectiveness of novel approaches to inhibiting or treating liver fibrosis can only offer moderate hope.

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