Inositol & its Phosphates: Basic Science to Practical Applications

by

A.K.M. Shamsuddin, Guang-Yu Yang

eISBN: 978-1-68108-007-9, 2015
ISBN: 978-1-68108-008-6



Indexed in: EBSCO.

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functio...[view complete introduction]
US $
Buy Personal eBook
49
Order Library eBook
196
Order Printed Copy
*104
Order PDF + Printed Copy (Special Offer)
*128

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology
Download Flyer

Sickle Cell Disease and Inositol Phosphates

- Pp. 176-186 (11)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Sickle cell disease (SCD) is a hereditary blood disorder due to a mutation in the hemoglobin gene, and characterized by abnormal hemoglobin S (HbS). Under hypoxic conditions, HbS polymerizes, inducing distortion of RBCs into rigid sickleshaped cells; in particular, homozygous SCD patients (SS) may experience painful episodes and complications due to vaso-occlusion (VOC) during their lifetime. There is no cure, but symptomatic management to improve anemia and lower the complications through blood transfusions is currently the most accepted therapy for those patients. Chronic red blood cell (RBC) exchanges or transfusion are effective in preventing the recurrence of VOC. While simple blood transfusions are important therapy for SCD, the goal of efficient transfusion is to increase the oxygen delivery and to prevent the sickling. It has been demonstrated that InsP<sub>6</sub>-loaded red blood cells (InsP<sub>6</sub>-RBCs) reduce the risks of sickling of sickle RBCs (SS RBCs) exposed to hypoxia.

Purchase Chapter  Book Details

Advertisement

International Conference On Drug Discovery & Therapy 2019Nobel LaureateFocus Medica

Webmaster Contact: info@benthamscience.org Copyright © 2018 Bentham Science