Advances in Modern Medicine


Kiyomi Taniyama, Wataru Kamiike

DOI: 10.2174/97816810802391150101
eISBN: 978-1-68108-023-9, 2017
ISBN: 978-1-68108-024-6

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Table of Contents


- Pp. i-vii (7)
Wataru Yasui
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- Pp. viii-ix (2)
Kiyomi Taniyama and Wataru Kamiike
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List of Contributors

- Pp. x-xvi (7)
Kiyomi Taniyama and Wataru Kamiike
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A New Therapeutic Strategy for Advanced Squamous Cell Carcinomas of the Head and Neck

- Pp. 3-11 (9)
Haruo Hirakawa, Yasuyuki Nishi, Taisuke Watanabe, Makoto Tada, Kiyomi Taniyama and Wataru Kamiike
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The Long-Term Outcomes of Partial Breast Irradiation Using External Beam after Breast Conserving Surgery

- Pp. 12-20 (9)
Michinori Yamamoto
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Is It Possible to Optimize Neoadjuvant Chemotherapy Response by EGFR and CK5/6 Expression Status in Breast Cancer Patients?

- Pp. 21-33 (13)
Nao Morii, Hiroyasu Yamashiro, Hirotoshi Takahashi and Kiyomi Taniyama
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Auto-Analysis of Immunohistochemical Findings for Breast Cancer

- Pp. 34-41 (8)
Kazuya Kuraoka, Kiyomi Taniyama, Miho Yoshida-Tanaka, Akihisa Saito, Nao Morii and Shinji Ozaki
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How does Pathology Clinic Have Effect on Mental State and Adjustment in Patients with Breast Cancer?

- Pp. 42-52 (11)
Miyuki Nagashima, Kiyomi Taniyama, Hanae Minami and Minoru Takebayashi
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Recurrence Pattern and Long-Term Survival After Two Types of VATS Lobectomy for Clinical T1N0 Lung Cancer

- Pp. 53-65 (13)
Yoshinori Yamashita and Hiroaki Harada
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The Role of DNA Methylation as A Biomarker in Lung Cancer: Prognostic Prediction and Early Detection

- Pp. 66-72 (7)
Hiroaki Harada, Kazuaki Miyamoto, Masaki Kuwahara and Yoshinori Yamashita
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Efficacy and Safety of Endoscopic Submucosal Dissection Using A Scissors-Type Knife for Early Colorectal Neoplasms

- Pp. 73-79 (7)
Toshio Kuwai, Toshiki Yamaguchi, Atsushi Yamaguchi, Hirotaka Kouno and Hiroshi Kohno
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Influence of Endoscopic Stent Insertion on Detection of Circulating Tumor Cells from Obstructing Colon Cancer

- Pp. 80-86 (7)
Shinya Yamashita, Masahiro Tanemura, Toshio Kuwai, Yosuke Shimizu, Harumi Tominaga and Nobutaka Hatanaka
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Clinical Outcome of Liver Resection in Single Center Experience: Laparoscopic versus Open Procedure

- Pp. 87-98 (12)
Toshimitsu Irei, Masahiro Tanemura, Masashi Inoue, Yosuke Shimizu, Harumi Tominaga and Nobutaka Hatanaka
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Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: Does TACE Have a Future?

- Pp. 99-111 (13)
Naoyuki Toyota, Takuji Yamagami, Noriaki Matsuura, Naoko Akiyama, Hiromi Miyoshi, Takahiro Sueoka and Kazuo Awai
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Immunotherapy for Pancreatic Cancer: Clinical Relevance of α-gal Epitope/Natural Anti-gal Antibody Reaction

- Pp. 112-125 (14)
Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Kiyomi Taniyama, Masaki Mori and Yuichiro Doki
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Evaluation of Cervical Liquid-Based Cytology in Glandular Abnormalities of Japanese Women

- Pp. 126-138 (13)
Yosuke Kawakami, Tamaki Toda, Toshinao Nishimura, Kazuya Kuraoka, Tomoya Mizunoe and Kiyomi Taniyama
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Clinical Application on Telomere Biology for Cancer

- Pp. 139-149 (11)
Toshihiro Matsuo, Hiroki Hachisuka, Takahiko Hamasaki, Yasunori Izuta and Norikazu Hamada
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Cancer Counseling and Pathology Clinic

- Pp. 150-159 (10)
Takako Nakanishi, Kyoko Kosugi, Chidori Teraoka, Terumi Aoshiba, Kazuya Kuraoka and Kiyomi Taniyama
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Late Endocrine Effect for Childhood Cancer Survivors

- Pp. 160-166 (7)
Shinichiro Miyagawa
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Changes in Esophageal Cancer Treatment Over the Past Decade at Our Hospital

- Pp. 167-172 (6)
Nobutaka Hatanaka and Jeong Ho Moon
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Adiponectin, Its Roles in Diabetes and Cardiovascular Disease

- Pp. 173-187 (15)
Morihiro Matsuda, Ritsu Tamura and Toshiharu Kawamoto
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Novel Strategy for Treatment in Type 2 Diabetes Mellitus: Targeting Systemic and Adipose Tissue Inflammation

- Pp. 189-195 (7)
Nozomu Kamei
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Improved Adaptation of Laparoscopic Partial Nephrectomy based on the Evaluation of Renal Function Using 99mTc-MAG3 Renal Imaging

- Pp. 196-204 (9)
Tsutomu Shimamoto, Masanobu Shigeta, Kenichiro Fukuoka, Fumihiro Satake and Shuntaro Koda
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Recent Findings in Genetic and Enzymatic Analysis of Newborn Screening-Positive Subjects Based on Tandem Mass Spectrometry

- Pp. 205-209 (5)
Keiichi Hara, Go Tajima, Satoshi Okada and Nobuo Sakura
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The Role of an Expert in Medical Engineering in Japan

- Pp. 210-219 (10)
Masashi Tagaya, Morihiro Matsuda, Shunsuke Ichikawa, Yasuyuki Nishi, Yasusuke Miyagatani and Toshiharu Kawamoto
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Depression: A Novel Mechanism of Antidepressant Action with a Focus on Astrocytes

- Pp. 220-232 (13)
Minoru Takebayashi, Kazue Hisaoka-Nakashima, Mami Okada- Tsuchioka, Chiyo Shibasaki, Hiromi Abe and Naoto Kajitani
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Advances in Electroconvulsive Therapy for Psychiatric Disorders

- Pp. 233-241 (9)
Chiyo Shibasaki and Minoru Takebayashi
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How Does Electroconvulsive Therapy Work in the Brain? –Involvement of the Astrocyte-Derived Synaptogenic Factor, Thrombospondin-1-

- Pp. 242-250 (9)
Mami Okada-Tsuchioka, Chiyo Shibasaki and Minoru Takebayashi
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Response to the Great East Japan Earthquake: Medical Aid Activities by National Hospital Organization

- Pp. 251-259 (9)
Tamami Umeda
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The Yin and Yang of Von Willebrand Factor in Thrombosis and Hemostasis: Lessons from Von Willebrand Disease and Thrombotic Thrombocytopenic Purpura

- Pp. 260-272 (13)
Toshiro Takafuta, Makoto Kaneko and Isaku Shinzato
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Topics in Neurology

- Pp. 273-286 (14)
Tsuyoshi Torii
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Impact of Dose Reduction on the Efficacy of Triple Therapy for Patients Infected with Genotype 1b and High Viral Loads

- Pp. 287-295 (9)
Hiroshi Kohno, Hirotaka Kouno, Toshiki Yamaguchi, Atsushi Yamaguchi and Toshio Kuwai
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Characteristics of Acute Cholangitis and Endoscopic Management of Elderly Patients at Our Institute

- Pp. 296-305 (10)
Atsushi Yamaguchi, Toshiki Yamaguchi, Toshio Kuwai, Hirotaka Kouno and Hiroshi Kohno
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Hyperbaric Oxygen Therapy for Salvage of Flaps with Unstable Blood Flow

- Pp. 306-316 (11)
Satoshi Onoda, Shogo Azumi, Yuki Miura and Narushi Sugiyama
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Efficacy of Wound Closure with Cyanoacrylate Glue for Total Knee Arthroplasty without Drain

- Pp. 317-324 (8)
Yasunori Izuta, Masanori Yasumoto, Masahiro Yoshikawa, Manabu Niitani, Norikazu Hamada and Takashi Sugita
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Effects of Switching from Allopurinol to Febuxostat in Chronic Kidney Disease Patients

- Pp. 325-333 (9)
Shunsuke Takahashi, Ayumu Nakashima, Asako Urabe, Yosuke Osaki and Takao Masaki
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Infection Control Program for MRSA in Intensive Care Units

- Pp. 334-340 (7)
Yasusuke Miyagatani, Masaki Murao, Kajie Ishitani and Chieko Senjyo
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Prevention and Management of Persistent Postoperative Pain - A Review of Literature and A Proposal of Therapeutic Strategy

- Pp. 341-353 (13)
Katsuyuki Moriwaki, Ken Hashimoto, Kazuhisa Shiroyama, Minoru Tajima, Mikako Sanuki and Shigeaki Kurita
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Bland-Altman Analysis for Method Comparisons

- Pp. 354-361 (8)
Noriaki Matsuura, Takahiro Sueoka, Hiromi Miyoshi, Naoko Akiyama, Naoyuki Toyota and Kazuo Awai
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Prospective Study of the Treatment of Biotin in Patients with Drug Erythema due to Gefitinib or Erlotinib

- Pp. 362-365 (4)
Yoshikazu Ogawa, Takayoshi Kiba, Kikuo Nakano, Sayoko Kajiume, Yuko Okada and Yasunori Ichiba
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Talking about Life Expectancy with Our Cancer Patients Considering Palliative Chemotherapy

- Pp. 366-375 (10)
Kikuo Nakano
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End-of-Life Care

- Pp. 376-389 (14)
Shoji Sunada, Naomi Sanemori, Kei Itagaki, Nobutaka Hatanaka, Yosuke Shimizu and Kikuo Nakano
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Humanized Mouse Models as An Experimental Tool to Investigate Disease Immunology

- Pp. 390-401 (12)
Takashi Onoe
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What are Clinical Studies?

- Pp. 403-406 (4)
Takayoshi Kiba
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The Hospital Information System Using Two Separate Virtual Servers Connected to the Internet with Strong Security

- Pp. 407-419 (13)
Toshiharu Kawamoto
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Dermoscopy for Pigmented Skin Lesions: Four Case Reports

- Pp. 420-426 (7)
Seiko Sanada
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A Case of Superior Sagittal Sinus Thrombosis Presented with Papilledema

- Pp. 427-433 (7)
Yumi Ishida and Ryoko Kanbara
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Verification of New Method for Stroke Volume Assessment by Echocardiography: Preliminary Study Report

- Pp. 434-437 (4)
Tatsuya Endo and Takashi Onoe
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Eosinophilic Pancreatitis with Psoriasis Vulgaris

- Pp. 438-446 (9)
Masashi Inoue, Masahiro Tanemura, Toshimitsu Irei, Nobutaka Hatanaka, Yuki Matsuzaka and Kazuya Kuraoka
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Acute Renal Failure Due to Ethylene Glycol Poisoning: A Case Report

- Pp. 447-450 (4)
Yosuke Osaki, Asako Urabe and Shunsuke Takahashi
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Intraductal Papilloma of the Breast with Necrosis Due to An Infarction: A Case Report

- Pp. 451-457 (7)
Akihisa Saito, Kazuya Kuraoka, Daiki Taniyama, Toshinao Nishimura, Shinji Ozaki and Kiyomi Taniyama
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Imprint Cytology of Extrarenal Retroperitneal Angiomyolipoma: A Case Report

- Pp. 458-463 (6)
Daiki Taniyama, Kazuya Kuraoka, Atsushi Yamaguchi, Masahiro Tanemura, Takuo Ito and Kiyomi Taniyama
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Internal Coil Trapping of a Ruptured PICAInvolved- Type Vertebral Artery Dissecting Aneurysm: A Case Report

- Pp. 464-471 (8)
Hideo Ohba, Shinji Ohba, Yoko Ito, Jumpei Oshita, Koki Yonezawa and Masahiro Hosogai
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An Approach for More Effective Detection of Clostridium Difficile in Patients

- Pp. 472-476 (5)
Kayoko Tadera, Yasushi Takashiro, Junichi Shimohana, Hideki Nakano, Takashi Onoe and Kiyomi Taniyama
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Quality Assurance of Immunohistochemistry for Breast Cancers using a Whole-slide Imaging System, Specified Software and Cell Lines

- Pp. 477-480 (4)
Miho Yoshida-Tanaka, Junichi Sakane, Yoshiko Kimura, Yoshimi Shitakubo, Kazuya Kuraoka and Kiyomi Taniyama
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Subject Index

- Pp. 481-488 (8)
Kiyomi Taniyama and Wataru Kamiike
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Congratulation on the Publication of “Advances in Modern Medicine”

We congratulate Dr. Kiyomi Taniyama and Dr. Wataru Kamiike on the publication of this excellent eBook entitled “Advances in Modern Medicine.” This publication is the outcome of more than ten years of effort at the Institute for Clinical Research, Kure Medical Center and Chugoku Cancer Center (KMCCCC), one of the major hospitals in the National Hospital Organization (NHO).

NHO is an independent administrative agency that manages 143 hospitals nationwide in Japan. The NHO is entrusted with three missions: providing medical care, promoting clinical research and educating medical care professionals. We are the largest domestic hospital network, providing services from acute to chronic care. There are more than 80 clinical research institutes attached to the hospitals. The Institute for Clinical Research of KMCCCC is one of the most powerful research institutes within NHO.

It has been pointed out recently that the clinical research should be more strenuously promoted in Japan, because domestically clinical research is not as active compared to basic medical research. As such, we are promoting high-quality clinical research including clinical trials with rapid progress by leveraging NHO’s large network. Looking forward, we expect continuous growth at the Institute for Clinical Research of KMCCCC, and hope that KMCCCC will be a leader for clinical research within NHO and also throughout Japan.

Hideo Kusuoka
President, National Hospital Organization,
Tokyo, Japan

Foreword 2

Toward Enhancement of Research Activities in Clinical Medicine

This publication was planned to celebrate the 10-year anniversary of the Institute for Clinical Research, Kure Medical Center and Chugoku Cancer Center (KMCCCC). Dr. Kiyomi Taniyama has served as the director of this institute throughout these 10 years. In addition, the publication is intended to commemorate the contributions and dedication of Dr. Wataru Kamiike, the president of KMCCCC, who will retire from his position in July.

The city of Kure, home to Kure Medical Center, used to be one of Japan’s major naval bases. After World War II, operation of the Kure Naval Hospital was taken over by the United Nations. The hospital was transferred to the Japanese government 10 years later and began to serve the Japanese people as a national hospital. Since then, KMCCCC has stood as the leading hospital in the Chugoku-Shikoku region. The role of the center has not been limited to clinical services for people in the Kure area, however. The center has also been expected to enhance and advance research activities in clinical medicine. The Institute for Clinical Research, KMCCCC was established and has functioned for this purpose.

Japan is generally acknowledged as a nation with the highest standards and achievements in scientific research. This is true for basic research such as research to elucidate the molecular mechanism of diseases. However, Japan’s achievements in clinical investigation are somewhat limited. International rankings of research activities have listed Japan 3rd in the field of basic medical sciences, but 18th in clinical medicine.

The National Hospital Organization is expected to encourage each member hospital to enhance its research activities in clinical medicine, including case reports, case-controlled studies, clinical trials, and cohort studies. Progress in medicine has been accomplished only through careful observation of clinical cases. Evidence that is inevitably needed for daily clinical decision making is only possible through documentation of clinical experiences.

We anticipate that the strength of research at the Institute for Clinical Research, KMCCCC, led by Dr. Taniyama, will continue to grow; it is our hope that the institute will contribute significant advancements to the medical sciences well into the future.

Takaaki Kirino
Former President, National Hospital Organization,
Tokyo, Japan

Foreword 3

10 Glorious Years for the National Hospital Organization Kure Medical Center and Chugoku Cancer Center

I want to express my great appreciation to Dr. Wataru Kamiike, president of national hospital organization (NHO) Kure Medical Center and Chugoku Cancer Center (KMCCCC), for his 10 years of significant contributions to the hospital. In his first five years, he helped me in his role as vice president to reengineer hospital management and in the second five years he managed the hospital as its president. Over the past decade, KMCCCC has made remarkable progress in both clinical and financial performance, which resulted in the hospital being acknowledged as one of the best hospitals among the more than 140 hospitals within the NHO. I believe that our highly advanced medical treatment and diligent nursing by the hospital staff have produced these outstanding results.

Publication of this eBook titled “Advances in modern medicine during the last decade” upon Dr. Kamiike's retirement and the tenth anniversary of Dr. Taniyama as director of the Clinical Research Institute affiliated with KMCCCC is extremely timely.

Dr. Taniyama will serve as the next president of KMCCCC. He has also contributed to the hospital’s distinguished development in both basic and clinical research. He is a highly regarded scientist in the field of clinical pathology not only domestically but also internationally. The memorandum of understanding between KMCCCC and Rajavithi Hospital in Thailand, the Kure International Medical Forum, and other international activities could not have been a great successes without his effort.

I thank everyone who has contributed to this eBook. I hope its publication will be a key milestone for the KMCCCC and that the center continues to grow and contribute to the advancement of modern medicine.

Fumitaka Saji
Honorary President, NHO Kure Medical Center & Chugoku Cancer Center,
Kure, Japan
CEO, Ashiya Municipal Hospital,
Ashiya, Japan

Foreword 4

Congratulatory Message for Dr. Kiyomi Taniyama, Kure Medical Center

It is my great honor and pleasure to write this congratulatory message for Dr. Kiyomi Taniyama on the occasion of the publication of his eBook, Advances in Modern Medicine during the Last Decade which coincides with the tenth anniversary of his chairmanship at the Institute for Clinical Research and his appointment as the President of National Hospital Organization Kure Medical Center and Chugoku Cancer Center (KMCCCC).

This eBook has taken up basic science, translational research and modern medicine in relation to both diagnosis and treatment, and reviews the latest cutting-edge therapeutics and diagnostics by KMCCCC's entire staff. I am deeply impressed by the eBook's descriptions of the achievements of the last decade. There is no doubt that this eBook is valuable to medical workers and researchers around the world.

I have known Dr. Taniyama for more than 30 years, since I became a member of the First Department of Pathology at Hiroshima University. Over the years, I have learned much, not only about medicine and pathology but also about social issues. I admire his foresight and action. In addition to his pathology practice and research, he organizes the annual Kure International Medical Forum and collaborates with many medical professionals across Asia. He is a leader and makes the resources of the Pathology Clinic available to cancer patients in Japan. When I, as the President, hosted the 103rd Annual Meeting the Japanese Society of Pathology in April 2014, he chaired the program committee of diagnostic pathology and ensured the great success of the meeting.

I wish Dr. Taniyama and his colleagues in KMCCCC all the best for a bright future. As the Director of Institute of Biomedical & Health Sciences, Hiroshima University, I look forward to our collaboration to achieve our goal of an even better understanding and treatment of our patients and the improvement of human health worldwide.

Wataru Yasui
Professor and Chairman, Department of Molecular Pathology
Director, Institute of Biomedical & Health Sciences
Dean, Hiroshima University Institute of Biomedical & Health Sciences,
Hiroshima, Japan


The National Hospital Organization (NHO) of Japan was rebuilt from the former National Hospitals of Japan 10 years ago in 2004. At almost the same time, Dr. Kiyomi Taniyama obtained his position as the director of the clinical research institute affiliated with the NHO Kure Medical Center and Chugoku Cancer Center (KMCCCC), Kure, Japan. Over the last decade, he has organized his research institute well and obtained many good results with the collaboration of the basic and translational research staff. Because the systems and equipment are often upgraded to keep pace with the latest trends in medicine, remarkable medical advances have been achieved during the last decade in our hospital, which is representative of the progress made in modern medicine, not only in Japan, but also around the world.

On June 30, 2014, Dr. Wataru Kamiike, is going to retire from the president of NHOKMCCCC that is one of the top five hospitals among the 143 NHO hospitals in Japan. Therefore, July in 2014 is a good time to celebrate Dr. Taniyama’s ten-year history as the director of clinical research center and promotion to the next president, as well as the retirement of Dr. Kamiike from the president. Fundamentally, this eBook will be a memorable token of this celebration, but it also represents the latest trends in modern medicine, covering a wide range of fields. As previously mentioned, this eBook will cover basic science, translational research, and modern medicine in relation to both diagnosis and treatment. This eBook will be full of reviews of cutting edge therapies and diagnostic techniques related to the fields of the authors, along with original articles with the latest data obtained by the authors.

Kiyomi Taniyama
Former Director, Institute for Clinical Research,
President, NHO KMCCCC, Kure,

Wataru Kamiike
Honorary President,

List of Contributors

Kiyomi Taniyama

Wataru Kamiike


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