Frontiers in Drug Design and Discovery

Volume 7

by

Atta-ur-Rahman, Mohammad Iqbal Choudhary

DOI: 10.2174/97816810816561160701
eISBN: 978-1-68108-165-6, 2016
ISBN: 978-1-68108-166-3
ISSN: 1574-0889 (Print)
ISSN: 2212-1064 (Online)



Indexed in: Scopus, EMBASE, EBSCO, Ulrich's Periodicals Directory.

Frontiers in Drug Design and Discovery is an eBook series devoted to publishing...[view complete introduction]
US $
Buy Personal eBook
99
Order Library eBook
396
Order Printed Copy
*119
Order PDF + Printed Copy (Special Offer)
*168

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology
Download Flyer

Angiogenesis Inhibitors from Natural Sources

- Pp. 152-222 (71)

Roslida Abd Hamid and Dayang Erna Zulaikha Awang Hamsin

Abstract

A multi-target strategies targeting on various biochemical and physiological pathways implicated in tumour pathogenesis should be developed with the ultimate aim to manage patients with cancer and reduce the normal-tissue toxicity. Tumor angiogenesis has been recently discovered as an important strategy in treating cancer as most tumors rely on angiogenesis to survive, develop, invade and metastasize. Targeting angiogenesis to inhibit the progression of tumorigenesis has recently been a focus in developing novel anti-cancer development. This is mainly due to the specificity that anti-angiogenic possesses: it targets on newly-formed blood vessels and spares the existing ones. With that being said, inhibiting angiogenesis is now considered a promising strategy in the development and selection of new anti-cancer drug candidates. To date, there are cytotoxic drugs which also exhibit antiangiogenic activity but not angiogenesis inhibitors in whole. In this chapter, we will be discussing selected natural sources including marine products which have been investigated for their antiangiogenic activities. Various methods in validating the effects as well as their possible multiple pathways will also be contended in this chapter.

Purchase Chapter  Book Details

Advertisement


Webmaster Contact: info@benthamscience.net Copyright © 2019 Bentham Science