Malignant Pleural Mesothelioma: Present Status and Future Directions


by

Tommaso Claudio Mineo

DOI: 10.2174/97816810819461160101
eISBN: 978-1-68108-193-9, 2016
ISBN: 978-1-68108-194-6



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Indexed in: EBSCO.

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the h...[view complete introduction]

Table of Contents

About the Editor

- Pp. i

Tommaso Claudio Mineo

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Foreword

- Pp. iii

Shaf Keshavjee

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Preface

- Pp. v-vi (6)

Tommaso Claudio Mineo

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Contributors

- Pp. vii-x (4)

Tommaso Claudio Mineo

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Holistic Care of People with Malignant Pleural Mesothelioma: A Thirty Year Perspective

- Pp. 3-11 (9)

Tom Treasure

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History of Malignant Pleural Mesothelioma

- Pp. 13-24 (12)

Peter Bartrip

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Natural History of Malignant Pleural Mesothelioma

- Pp. 25-31 (7)

Anish Thomas and Raffit Hassan

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Epidemiology of Malignant Pleural Mesothelioma in Europe

- Pp. 33-52 (20)

Andrew Darnton, Clare Gilham and Julian Peto

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Epidemiology of Malignant Pleural Mesothelioma in the Americas

- Pp. 53-71 (19)

Bruce W. Case

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Epidemiology of Malignant Pleural Mesothelioma in Japan and South Korea

- Pp. 73-81 (9)

Takashi Nakano, Kozo Kuribayashi, Soon-Hee Jung and Hyoung-Ryoul Kim

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Epidemiology of Malignant Pleural Mesothelioma in Australia

- Pp. 83-93 (11)

Nicholas de Klerk, Fraser Brims, Alison Reid, Peter Franklin, Nola Olsen, Tim Threlfall, Keith Shilkin and A. William Musk

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Epidemiology of Malignant Pleural Mesothelioma in Africa

- Pp. 95-113 (19)

Gill Nelson and Jim teWaterNaude

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Asbestos and Malignant Pleural Mesothelioma

- Pp. 115-128 (14)

Matthew J. Soeberg and Nico van Zandwijk

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Environmental Non-Asbestos Related Causes of Malignant Pleural Mesothelioma

- Pp. 129-144 (16)

Francine Baumann and Jean-Paul Ambrosi

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Virus Oncogenesis of Malignant Pleural Mesothelioma

- Pp. 145-154 (10)

Giovanni Gaudino, Fang Qi, Haining Yang and Michele Carbone

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Genetics of Malignant Pleural Mesothelioma

- Pp. 155-168 (14)

Dean A. Fennell, Annabel J. Sharkey and Sara Busacca

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Biomolecular Pathways and Malignant Pleural Mesothelioma

- Pp. 169-192 (24)

Marie-Claude Jaurand and Didier Jean

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Somatic and Germline BAP1 Mutations in Malignant Mesothelioma

- Pp. 193-203 (11)

Andrea Napolitano, Laura Pellegrini, Haining Yang and Michele Carbone

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Anatomic Pathology of Malignant Pleural Mesothelioma

- Pp. 205-212 (8)

Alfredo D’Avino and Alfonso Baldi

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Imaging Evaluation in Malignant Pleural Mesothelioma

- Pp. 213-231 (19)

Beth A. Ripley and Ritu R. Gill

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Present Role of Cytology in Diagnosing Malignant Pleural Mesothelioma

- Pp. 233-246 (14)

Anders Hjerpe and Katalin Dobra

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Serum Biomarkers in Malignant Pleural Mesothelioma

- Pp. 247-256 (10)

Ian M. Dick and Jenette Creaney

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Prognostic Factors in Malignant Pleural Mesothelioma

- Pp. 257-283 (27)

Tommaso Claudio Mineo and Vincenzo Ambrogi

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Pleural Effusion Management in Malignant Pleural Mesothelioma

- Pp. 285-303 (19)

Maree Azzopardi and Gary Y.C. Lee

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Chemotherapy in Malignant Pleural Mesothelioma

- Pp. 305-320 (16)

Wei-Sen Lam and Anna K. Nowak

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Radiation Therapy of Malignant Pleural Mesothelioma

- Pp. 321-334 (14)

Hale Basak Caglar

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Novel Genetic Therapies in Malignant Pleural Mesothelioma

- Pp. 335-346 (12)

Assunta De Rienzo and Raphael Bueno

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Virus Therapies in Malignant Pleural Mesothelioma

- Pp. 347-361 (15)

Manish R. Patel

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Future Prospects in Chemotherapy for Malignant Pleural Mesothelioma

- Pp. 363-386 (24)

Xiang Hua Zhang, Birgitta I Hiddinga and Jan P van Meerbeeck

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Staging Systems and Current Guidelines in Malignant Pleural Mesothelioma

- Pp. 387-398 (12)

Christopher Cao

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Thoracoscopy in Diagnosis and Treatment of Malignant Pleural Mesothelioma

- Pp. 399-411 (13)

Rocco Bilancia, Annabel Sharkey and David A. Waller

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Value of Extrapleural Pneumonectomy in Malignant Pleural Mesothelioma

- Pp. 413-427 (15)

Andrea S. Wolf and Raja H. Flores

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Lung Sparing Surgery for Malignant Pleural Mesothelioma

- Pp. 429-440 (12)

Robert B. Cameron

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Surgical Treatment after Radiotherapy in Malignant Pleural Mesothelioma

- Pp. 441-451 (11)

Laura Donahoe and Marc de Perrot

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Surgical Treatment after Chemotherapy in Malignant Pleural Mesothelioma

- Pp. 453-467 (15)

Isabelle Opitz and Walter Weder

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Results after Intraoperative Therapy in Malignant Pleural Mesothelioma

- Pp. 469-478 (10)

Shamus R. Carr and Joseph S. Friedberg

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Complications after Surgery for Malignant Pleural Mesothelioma

- Pp. 479-490 (12)

Zeynep Bilgi and Hasan F. Batirel

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Clinical Impact of Surgery for Malignant Pleural Mesothelioma

- Pp. 491-514 (24)

Tommaso Claudio Mineo and Vincenzo Ambrogi

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Analysis of Therapies for Malignant Pleural Mesothelioma: Words that Count, Numbers that Speak

- Pp. 515-520 (6)

Francesca Fiorentino and Tom Treasure

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Subject Index

- Pp. 521-528 (8)

Tommaso Claudio Mineo

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Foreword

Mesothelioma remains an unusual cancer that a limited number of centers treat in high volumes across the globe. Industrialized countries are currently experiencing an epidemic of mesothelioma and the incidence is expected to continue to rise for the next decade at least.

The outcome of mesothelioma is poor with an overall median survival ranging between 10 and 20 months. However, due to the rising incidence and poor outcome, the amount of research in the clinical setting and in the laboratory has rapidly expanded over the past 15 years. Hence, it is important that all physicians involved in the care of patients with mesothelioma be familiar with the important issues related to this disease to have a thorough understanding of the tumor biology, staging process, treatment options and the role of multidisciplinary approach.

Currently, cisplatin combined with an anti-folate agent has been recognized as standard of care for non-surgical patients with advanced disease. In the next decade, however, it is very likely that we will see new standards coming forward.

In this book, edited by Professor Mineo, many world renowned contributors in the field of mesothelioma present an update of their research and clinical experience, putting their findings in perspective. This book provides an excellent companion for physicians focusing on mesothelioma research and treatment as well as for individuals who may only see these patients infrequently.

Shaf Keshavjee
University Health Network
Division of Thoracic Surgery
Department of Surgery
University of Toronto
Canada


Preface

In 1974, I performed my first extrapleural pneumonectomy for mesothelioma on a 58 years old man. He was a heavy smoker with a history of exposure to asbestos. The local aggressiveness of the tumor was impressive and I was struck from the high demolitive nature of the operation. I took a Polaroid of the surgical specimen - which now appears at the end of this preface - as a sort of remembrance of that naive feeling.

At that time, my expectancy was that future medical achievements would offered a chance of cure to patients with this malignancy. Over the years, I have been often renewing this question to myself: is there a way to combat mesothelioma effectively? Is this actually an invincible disease?

Recently, I have done my last operation for mesothelioma. This time, the patient was a woman who had never smoked in her life. She also had never been in contact with any evident source of exposure to asbestos. While performing pleurectomy/decortication, I was considering that surgery has not substantially changed over decades. The main goal of surgery continues to be symptom palliation, as it fails to improve significantly the chance of long-term survival in many instances.

Malignant pleural mesothelioma remains an extremely severe condition worldwide. Statistical figures are impressive. The overall incidence is expected to rise in the next future, a fact which also carries social and economical issues. The malignancy conceals so many biological secrets, but the first glimmers of light are already evident. This situation urgently calls for a multidisciplinary effort aimed at improving the extremely poor prognosis of these unlucky patients.

So far, what has changed on malignant pleural mesothelioma management? In order to better reply this question, my idea was to involve all my colleagues and friends - each one having a highest level of expertise in this field ¬- in this Editorial project. All the most relevant innovations on pleural mesothelioma are put together in this E-book, which is structured in keeping with a multidisciplinary view of this disease. In this regard, I believe that the electronic format would have been the ideal one to improve the accessibility to the contents. We well know how much medical students and surgical residents of the new generation are familiar with mobile phones and laptops. A traditional paper book would have probably failed the mission of reaching out to our pupils.

Finally, I would like to thank all the contributors of this book. All of them are re-nowned scientists devoted to specific settings of malignant pleural mesothelioma. The book would have not been possible without their cooperation and friendship. Their progresses are our hopes; according to these contributions we will be able to reduce an increasing number of patients from the high rate of mortalities still occurring as a result of this dreadful disease.

Tommaso Claudio Mineo
Department of Thoracic Surgery
Tor Vergata University Rome
Italy

List of Contributors

Editor(s):
Tommaso Claudio Mineo
Department of Thoracic Surgery
Tor Vergata University Rome
Italy




Contributor(s):
Ambrogi Vincenzo
Department of Thoracic Surgery
Rome
Italy


Ambrosi Jean-Paul
CEREGE
Aix-en-Provence
France


Azzopardi Maree
Respiratory Dept, Sir Charles Gairdner Hospital, Pleural Medicine Unit, Institute for Respiratory Health
University of Western Australia
Perth
Australia


Baldi Alfonso
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies
Second University of Naples
Caserta
Italy


Bartirel Hasan F.
Department of Thoracic Surgery, Faculty of Medicine
Marmara University
Istanbul
Turkey


Bartrip Peter
Centre for Socio-Legal Studies
University of Oxford
Oxford
United Kingdom


Baumann Francine
ERIM
University of New Caledonia
Noumea
New Caledonia


Bilancia Rocco
Department of Thoracic Surgery, Glenfield Hospital
University Hospitals of Leicester
Leicester
United Kingdom


Bilgi Zeynep
Department of Thoracic Surgery, Faculty of Medicine
Marmara University
Istanbul
Turkey


Brims Fraser
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia; School of Population Health
Curtin University
Australia


Bueno Raphael
Thoracic Surgery Oncology laboratory and International Mesothelioma Program, Division of Thoracic Surgery, Brigham and Women’s Hospital
Harvard Medical School
Boston, MA
United States


Busacca Sara
Cancer Research UK Leicester Centre
University of Leicester
Leicester
United Kingdom


Caglar Hale Basak
Department of Radiation Oncology
Medipol University Hospital
Istanbul
Turkey


Cameron Robert B.
Cardiothoracic Surgery and Surgical Oncology, UCLA
Jonsson Comprehensive Cancer
Los Angeles, CA
United States


Cao Christopher
The Collaborative Research (CORE) Group
Macquarie University
Sydney
Australia


Carbone Michele
University of Hawaii Cancer Center
Honolulu, HI
United States


Carr Shamus R.
Division of Thoracic Surgery
University of Maryland School of Medicine
Baltimore, MD
United States


Case Bruce W.
Departments of Pathology and Epidemiology
McGill University
Montréal
Canada


Creaney Jenette
National Centre for Asbestos Related Diseases
School of Medicine, University of Western Australia
Nedlands
Australia


Darnton Andrew
Statistics and Epidemiology Unit
Science Directorate, Health & Safety Executive
Bootle
United Kingdom


D'Avino Alfredo
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies
Second University of Naples
Caserta
Italy


Klerk Nicholas De
Telethon Kids Institute
Perth
Australia


Perrot Mark De
Toronto Mesothelioma Research Program
Toronto
Canada


Rienzo Assunta De
Thoracic Surgery Oncology laboratory
Boston, MA
United States


Ian M. Dick
National Centre for Asbestos Related Diseases, School of Medicine
Nedlands,
Australia


Katalin Dobra
Division of Clinical Pathology/Cytology,
Huddinge
Sweden


Laura Donahoe
Toronto Mesothelioma Research Program,
Toronto.
Canada


Dean A. Fennell
Cancer Research UK Leicester Centre
Leicester,
United Kingdom


Francesca Fiorentino
National Heart and Lung Institute
United Kingdom
London


Raja H. Flores
Department of Thoracic Surgery
New York, NY
United States


Peter Franklin
School of Population Health
Perth
Australia


Joseph S. Friedberg
Division of Thoracic Surgery
Baltimore, MD,
United States


Giovanni Gaudino
University of Hawaii Cancer Center
Honolulu, HI
United States


Clare Gilham
London School of Hygiene and Tropical Medicine
United Kingdom
London


Nelson Gill
School of Public Health
South Africa


Ritu R. Gill
Department of Radiology
Boston, MA,
United States


Raffit Hassan
Thoracic and GI Oncology Branch
Bethesda, MD,
United States


Birgitta I Hiddinga
Department of Thoracic Oncology
Edegem,
Belgium


Anders Hierpe
Division of Clinical Pathology/Cytology
Huddinge
Sweden


Jaurand Marie-Claude
INSERM, UMR-1162, Génomique fonctionnelle des tumeurs solides
Paris,
France


Didier Jean
INSERM, UMR-1162, Génomique fonctionnelle des tumeurs solides
Paris,
France


teWaterNaude Jim
Mesothelioma Interest Group,
Cape Town
South Africa


Jung Soon-Hee
Department of Pathology,
Wonju,
South Korea


Shaf Keshavjee
Division of Thoracic Surgery
Toronto,
Canada


Hyoung-Ryoul Kim
Department of Occupational and Environmental Medicine,
Seul,
South Korea


Kozo Kuribayashi
Division of Respiratory Medicine, Department of Internal Medicine
Hyogo,
Japan


Wei-Sen Lam
Department of Medical Oncology
Nedlands, WA, 6009,
Australia


Gary Y.C. Lee
Respiratory Dept, Sir Charles Gairdner Hospital
Perth,
Australia


Tommaso Claudio Mineo
Department of Thoracic Surgery
Rome,
Italy


William A. Musk
School of Population Health, University of Western Australia
RWestern Australia
Australia


Takashi Nakano
Division of Respiratory Medicine,
Hyogo
Japan


Napolitano Andrea
University of Hawaii Cancer Center
Honolulu, HI,
United States


Anna K. Nowak
School of Medicine and Pharmacology
Crawley
Australia


Opitz Isabelle
Division of Thoracic Surgery
University Hospital Zurich
Zurich
Switzerland


Patel Manish R.
Department of Medicine, Division of Hematology, Oncology, and Transplantation
University of Minnesota Medical School
Minneapolis
United States


Peto Julian
London School of Hygiene and Tropical Medicine
Honolulu, HI
United States


Qi Fang
University of Hawai’i Cancer Center
Honolulu, HI
United States


Reid Alison
School of Population Health, Curtin University
Perth
Australia


Ripley Beth A.
Department of Radiology, Brigham & Women’s Hospital
Harvard Medical School
Boston
United States


Sharkey Annabel J.
Cancer Research UK Leicester Centre
University of Leicester
Leicester
United Kingdom


Shilkin Keith
School of Pathology and Laboratory Medicine
University of Western Australia and Pathwest Laboratory Medicine
Perth
Australia


Soeberg Matthew J.
Asbestos Diseases Research Institute
Sydney
Australia


Thomas Anish
Thoracic and GI Oncology Branch, National Cancer Institute
National Institutes of Health
Bethesda, MD
United States


Threlfall Tim
Western Australian Department of Health, East Perth, Western Australia
Perth
Australia


Treasure Tom
Clinical Operational Research Unit, University College London
London
UK


Van Meerbeck Jan P.
Thoracic Oncology, MOCA, Antwerp University Hospital
Edegem
Belgium


Van Zandwijk Nico
Asbestos Diseases Research Institute
Sydney
Australia


Waller David A.
Department of Thoracic Surgery, Glenfield Hospital
University Hospitals of Leicester
Leicester
United Kingdom


Weder Walter
Division of Thoracic Surgery
University Hospital Zurich
The Icahn School of Medicine at Mount Sinai
Zurich
Switzerland


Wolf Andrea S.
Department of Thoracic Surgery
The Icahn School of Medicine at Mount Sinai
New York, NY
United States


Yang Haining
University of Hawaii Cancer Center
Honolulu, HI
United States


Zang Xiang Hua
Department of Thoracic Oncology
MOCA, Antwerp University Hospital
Wilrijkstraat 10, 2650 Edegem
Belgium




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