Frontiers in Medicinal Chemistry

Volume 9

by

Atta-ur-Rahman , M. Iqbal Choudhary , Allen B. Reitz

DOI: 10.2174/97816810824931160901
eISBN: 978-1-68108-249-3, 2016
ISBN: 978-1-68108-250-9
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)



Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO., Ulrich's Periodicals Directory.

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Purinergic Receptors and Pain–An Update

- Pp. 3-55 (53)

Geoffrey Burnstock

Abstract

There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and musculoskeletal nociception and on the roles played by P2X3, P2Y2/3, P2X4, P2X7 and P2Y12 receptors in neuropathic and inflammatory pain. Current developments of compounds for the therapeutic treatment of both visceral and neuropathic pain are discussed.

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11th Joint Meeting on Medicinal Chemistry 2019 (JMMC 2019)

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