Frontiers in Clinical Drug Research -CNS and Neurological Disorders

Volume 4

by

Atta-ur-Rahman

DOI: 10.2174/97816810829501160401
eISBN: 978-1-68108-295-0, 2016
ISBN: 978-1-68108-296-7
ISSN: 2451-8883 (Print)
ISSN: 2214-7527 (Online)



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Indexed in: EBSCO.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is an eBook series that brings updated reviews t...[view complete introduction]

Table of Contents

Preface

- Pp. i-ii (2)

Atta-ur-Rahman

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List of Contributors

- Pp. iii-iv (2)

Atta-ur-Rahman

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Multiple Sclerosis Drug Therapy: From the Classical Pharmaceutical Down to Cellular and Molecular Approach

- Pp. 3-113 (111)

Roberta Rigolio, Elisa Ballarini, Maria Grimoldi, Margherita Gardinetti and Gabriele Di Sante

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Prospective Therapies for Alzheimer Disease: Biomarkers, Clinical Trials and Preclinical Research

- Pp. 114-191 (78)

Jofre Guell-Bosch, Gisela Esquerda-Canals, Laia Montoliu-Gaya and Sandra Villegas

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At the Crossroad between Neuronal Hyperexcitability and Neuroinflammation: New Therapeutic Opportunities for Alzheimer’s Disease?

- Pp. 192-226 (35)

Chelsea Cavanagh and Slavica Krantic

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Treatment of Diabetic Neuropathy - Current Possibilities and Perspectives

- Pp. 227-296 (70)

Jarmila Vojtkova, Miriam Ciljakova and Peter Banovcin

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The Now and Tomorrow of Migraine Treatments

- Pp. 297-345 (49)

Sefik Evren Erdener and Turgay Dalkara

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The Now and Tomorrow of Ischemic Stroke Treatment

- Pp. 346-370 (25)

Ethem Murat Arsava and Turgay Dalkara

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Subject Index

- Pp. 371-372 (2)

Atta-ur-Rahman

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Preface

The book series Frontiers in Clinical Drug Research – CNS and Neurological Disorders contains the most noteworthy recent developments for the treatment of several neurological disorders. The volume 4 of this book series is a collection of well written cutting edge reviews contributed by some of the most prominent researchers in the field.

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the immune system attacks the myelin and causes communication complications between the brain and the body. It affects some two million persons across the world. In chapter 1, Rigolio et al. present an excellent overview of the old and new cellular and molecular therapeutic approaches to fight MS neurodegenerative progression.

Alzheimer’s disease (AD) is the most common age-related multifactorial neurodegenerative disease which is described as the failure of cognitive performance and behavioral capabilities and there is a desperate need for the treatment to prevent, stop or reverse this devastating disorder. The magnitude of the problem can be judged from the fact that of the 46.8 million people suffering from dementia worldwide, the majority belong to those suffering from AD and this number is expected to triple over the next 30 years. In chapter 2 Villegas et al. discuss several biomarkers for early detection, clinical trials under way on new drugs, and preclinical research involving different approaches to tackle Alzheimer’s disease.

In chapter 3 Cavanagh & Krantic discuss two aspects of AD, hyperexcitability and neuroinflammation, which can be used for future therapeutic intervention. They also summarize the studies, which are related to hyperexcitability and neuroinflammation in the early phases of the disease.

Diabetic neuropathy (DN) is characterized by neurodegeneration associated with diabetes mellitus which belongs to the earliest and most frequent chronic diabetic complications. It may occur in clinical form or in subclinical form. High blood sugar affects nerve fibers throughout the body, but diabetic neuropathy most often damages nerves in the legs and feet. Vojtková et al. in chapter 4 present a comprehensive review about current possibilities and future perspectives in the management and treatment of diabetic neuropathy.

Migraine is a primary headache disorder characterized by moderate to severe recurrent headaches. Erdener & Dalkara in chapter 5 focus on the current and future therapeutic agents for acute and prophylactic migraine treatment and their mechanisms of action. In chapter 6, the Arsava and Dalkara present a review on developments in the treatment of acute ischemic stroke. They also discuss the recent advancements in the secondary prophylaxis of ischemic stroke.

The 4th volume of the book series represents the results of a significant amount of work by eminent researchers in the field. I am grateful to the authors for these valuable contributions. I also wish to thank the excellent team of Bentham Science Publishers, especially Mr. Shehzad Naqvi (Senior Manager Publications), led by Mr. Mahmood Alam (Director Publications), who deserve our appreciation.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Kings College, University of Cambridge
Honorary Life Fellow
Cambridge
UK




Contributor(s):
Chelsea Cavanagh
Department of Neuroscience
Douglas Hospital Research Center
Montreal
Quebec


Elisa Ballarini
Experimental Neurology Unit
School of Medicine and Surgery, Università Milano-Bicocca, Via Cadore 48
20900 Monza
Italy
/
NeuroMI- Milan Center for Neuroscience
San Gerardo Hospital, Via Pergolesi, 33 - 20052
Monza
Italy


Ethem Murat Arsava
Department of Neurology
Faculty of Medicine, Hacettepe University
Ankara
Turkey


Gabriele Di Sante
Institute of General Pathology
Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168
Rome
Italy


Gisela Esquerda-Canals
Protein Folding and Stability Group, Departament de Bioquímica i Biologia Molecular, Unitat de Biociències, Universitat Autònoma de Barcelona
Campus Bellaterra 08193
Cerdanyola del Vallès
Spain
/
Departament de Biologia Cellular, Fisiologia i Immunologia, Unitat de Citologia i Histologia, Universitat Autònoma de Barcelona
Campus Bellaterra 08193
Cerdanyola del Vallès
Spain


Jofre Güell-Bosch
Protein Folding and Stability Group, Departament de Bioquímica i Biologia Molecular, Unitat de Biociències, Universitat Autònoma de Barcelona
Campus Bellaterra 08193
Cerdanyola del Vallès
Spain


Jarmila Vojtková
Department of Pediatrics
Comenius University in Bratislava, Jessenius Faculty of Medicine and University Hospital Martin
Martin
Slovakia


Laia Montoliu-Gaya
Departament de Biologia Cellular, Fisiologia i Immunologia, Unitat de Citologia i Histologia, Universitat Autònoma de Barcelona
Campus Bellaterra 08193
Cerdanyola del Vallès
Spain


Maria Grimoldi
Experimental Neurology Unit
School of Medicine and Surgery, Università Milano-Bicocca, Via Cadore 48
20900 Monza
Italy


Margherita Gardinetti
Experimental Neurology Unit
School of Medicine and Surgery, Università Milano-Bicocca, Via Cadore 48
20900 Monza
Italy


Miriam Čiljaková
Department of Pediatrics
Comenius University in Bratislava, Jessenius Faculty of Medicine and University Hospital Martin
Martin
Slovakia


Peter Bánovčin
Department of Pediatrics
Comenius University in Bratislava, Jessenius Faculty of Medicine and University Hospital Martin
Martin
Slovakia


Roberta Rigolio
Experimental Neurology Unit
School of Medicine and Surgery, Università Milano-Bicocca, Via Cadore 48
20900 Monza
Italy
/
NeuroMI- Milan Center for Neuroscience
San Gerardo Hospital, Via Pergolesi, 33 - 20052
Monza
Italy


Sandra Villegas
Protein Folding and Stability Group, Departament de Bioquímica i Biologia Molecular, Unitat de Biociències, Universitat Autònoma de Barcelona
Campus Bellaterra 08193
Cerdanyola del Vallès
Spain


Slavica Krantic
Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138
Centre de Recherche, des Cordeliers
F-75006, Paris
France
/
INSERM, UMR_S 1138
Centre de Recherche des Cordeliers
F-75006, Paris
France
/
Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138
Centre de Recherche des Cordeliers
F-75006, Paris
France
/
Centre National de la Recherche Scientifique (ou CNRS) ERL 8228
Centre de Recherche des Cordeliers
Paris
France


Sefik Evren Erdener
Department of Neurology
Faculty of Medicine, Hacettepe University
Ankara
Turkey


Turgay Dalkara
Department of Neurology
Faculty of Medicine, Hacettepe University
Ankara
Turkey
/
Institute of Neurological Sciences and Psychiatry
Hacettepe University
Ankara
Turkey




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