Topics in Anti-Cancer Research

Volume 5


Atta-ur-Rahman / Khurshid Zaman

DOI: 10.2174/97816810833391160501
eISBN: 978-1-68108-333-9, 2016
ISBN: 978-1-68108-334-6
ISSN: 2468-5860 (Print)
ISSN: 2213-3585 (Online)

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Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

The fifth volume of this series entitled “Topics in Anti-Cancer Research” presents an overview of recent developments in the field of ...[view complete introduction]
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Table of Contents


- Pp. i
Atta-ur-Rahman and Khurshid Zaman

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- Pp. ii-iii (2)
Atta-ur-Rahman and Khurshid Zaman
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List of Contributors

- Pp. iv-v (2)
Atta-ur-Rahman and Khurshid Zaman
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Advances in Anti-Cancer Drug Development Targeting Carbonic Anhydrase IX and XII

- Pp. 3-42 (40)
Mam Y. Mboge, Robert McKenna and Susan C. Frost

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Tumor Homing Peptides: Promising Futuristic Hope for Cancer Therapy

- Pp. 43-86 (44)
Rekha Khandia, Swati Sachan, Ashok K. Munjal, Ruchi Tiwari and Kuldeep Dhama

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Cell-Based Anticancer Drug Delivery Systems

- Pp. 87-120 (34)
Darinka Gjorgieva Ackova, Katarina Smilkov and Darko Bosnakovski

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Studies on Patents and the Associated Anti-cancer Drug Development in China

- Pp. 121-204 (84)
Jinhua Shen, Guohua Zhu, Lichun Sun, Gengping Zhang, Leyang Qin, Feng Yang, Ruru Gao and Xinhong Fan

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Recent Developments in Anticancer Agents Targeting Heat Shock Proteins

- Pp. 205-224 (20)
Aykut Özgür, Banu Bayram, Lütfi Tutar and Yusuf Tutar

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Author Index

- Pp. 225
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Subject Index

- Pp. 226-227 (2)
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The fifth volume of the Book series entitled “Topics in Anti-Cancer Research” is based on new contributions from eminent scientists working in the field of cancer research and therapy. The topics presented cover recent advances in cancer drug development targeting carbonic anhydrase IX and XII.

Frost et al. discuss the roles of carbonic anhydrase IX and XII in stabilizing pHe in physiological conditions and their use in anti-cancer targets. Studies on the recent patents of CA IX and XII targeted inhibitors are also discussed, especially with reference to sulfonamide-based small molecule inhibitors, derivatives of boron cluster compounds, metal complexes of poly(carboxyl)amine-containing ligands, nitroimidazole-, ureidosulfonamide and coumarin-based compounds and G250 and A610 monoclonal antibodies for cancer therapy.

Zhu et al. present an analysis of patents and patent applications associated with cancer drug development in China including existing regulatory policies, data and trend of Chinese domestic anti-cancer drug patents, exploration of Chinese applicants in other countries and recent case study of liver cancer. Bosnakovski has reviewed the promising field of cell based anti-cancer drug delivery systems and studied recent patents and current developments.

Tutar discuss the potential role of heat shock proteins in the metabolic processes of cancer cells and the interaction of heat shock proteins with other proteins and kinases to inhibit cancer cells leading to apoptosis, for better therapy. Patents using this mechanism are also reviewed.

Dhama et al. reviewed the data of recent searches and patents on tumor homing peptides (THPs) functioning for targeted drug delivery in cancer cell and the significance of THPs in cancer therapy.

We expect that these topics on new drug targets, drug delivery approaches and techniques in cancer research & therapy will prove to be of great interest to researchers and scientists in the field of cancer and its treatment.

The editors are obliged to the authors for their excellent and timely contributions and to the reviewers for their thorough reviewing, which has enabled us to improve the quality of these chapters. We also extend our thanks to Mr. Mahmood Alam and Mrs. Rafia Rehan, as well as other colleagues of Bentham Science Publishers, for their rigorous participation and support in the accomplishment of the present eBook.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge


Khurshid Zaman
Bentham Science Publishers

List of Contributors

Atta-ur-Rahman / Khurshid Zaman
University of Cambridge
Bentham Science Publishers

Darko Bosnakovski
Faculty of Medical Sciences
University "Goce Delcev" Stip
Krste Misirkov bb, 2000 Stip
R. Macedonia

Kuldeep Dhama
Division of Pathology
ICAR-Indian Veterinary Research Institute
Izatnagar, Bareilly
Uttar Pradesh – 243122

Susan C. Frost
University of Florida, College of Medicine
Department of Biochemistry and Molecular Biology, Box 100245
Gainesville, FL 32610

Lichun Sun
Department of Medicine
Tulane University Health Sciences Center
New Orleans, LA 70002

Yusuf Tutar
Cumhuriyet University
Faculty of Pharmacy, Department of Basic Sciences
Division of Biochemistry


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