Frontiers in Clinical Drug Research-Hematology

Volume 3

by

Atta-ur-Rahman FRS

DOI: 10.2174/97816810836741180301
eISBN: 978-1-68108-367-4, 2018
ISBN: 978-1-68108-368-1
ISSN: 2467-9585 (Print)
ISSN: 2352-3239 (Online)



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Table of Contents

Preface

- Pp. i
Atta-ur- Rahman
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List of Contributors

- Pp. ii
Atta-ur- Rahman
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Advances in the Understanding and Treatment of Immune Thrombocytopenia

- Pp. 1-28 (28)
Jose Perdomo
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Recent Developments in Chronic Myeloid Leukemia Biology and Treatment

- Pp. 29-72 (44)
Massimiliano Bonifacio and Claudio Sorio
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Role of Immunomodulatory Drugs in the Treatment of Lymphoid and Myeloid Malignancies

- Pp. 73-137 (65)
Ota Fuchs
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Pediatric Hematological Malignancies – Clinical Manifestation, Treatment and Follow-Up

- Pp. 138-183 (46)
Naga Ramya Lanka and Krishna Kanth Pulicherla
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Novel Therapies and Immunotherapeutic Approaches to Treat Childhood Leukemia

- Pp. 184-219 (36)
Natasha Ali
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Erythrocyte Turnover and Erythropoietic Patterns in Two Different Experimental Mouse Models of Anemia

- Pp. 220-251 (32)
Sreoshi Chatterjee and Rajiv K. Saxena
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Subject Index

- Pp. 252-260 (9)
Atta-ur- Rahman
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Preface

The present third volume of this eBook series: Frontiers in Clinical Drug Research – Hematology comprises six comprehensive chapters covering immune thrombocytopenia, chronic myeloid leukemia, lymphoid and myeloid malignancies, pediatric hematological malignancies, childhood leukemia and erythrocyte turnover and erythropoietic patterns in experimental mouse models of anemia.

In chapter 1, Jose Perdomo presents the current understanding of etiology of immune thrombocytopenia for the enhancement and development of existing and new treatments. In chapter 2, Bonifacio and Sorio discuss the recent developments in the treatment of chronic myeloid leukemia treatment based on understanding that BCR-ABL1 oncogene is alone not responsible for the occurrence, progression and maintenance of disease. The emerging role of phosphatases in the pathogenesis of hematologic malignancies as new therapeutic approaches has been discussed. Ota Fuchs in chapter 3, review the role of various immunomodulatory drugs in the treatment of lymphoid and myeloid malignancies.

Hematological malignancies arise in blood forming tissue such as in the bone marrow. Diagnosis at the initial stages could lead to the successful treatment and eventually to a decline in mortality rate. It requires a detailed understanding of etiology of disease. In chapters 4 and 5, various aspects of pediatric leukemia has been discussed. Lanka and Pulicherla in chapter 4, focus on the clinical strategies and treatment approaches to combat pediatric hematological malignancies. Natasha Ali in chapter 5 reviews the new therapeutic agents for treating pediatric leukemia including nucleoside analogues, monoclonal antibodies, CAR T cells, tyrosine kinase inhibitors, epigenetic agents and proteasome inhibitors. In the last chapter of this book, Chatterjee and Saxena have compared the erythrocyte turnover and erythropoietic patterns in two different experimental mouse models of anemia.

I hope that the pharmaceutical scientists and postgraduate students will find these reviews valuable in order to seek updated and important content for the development of clinical trials and formulating research plans in these fields.

I am grateful for the timely efforts made by the editorial personnel of Bentham Science Publishers, especially Mr. Mahmood Alam (Director Publications), Mr. Shehzad Naqvi (Senior Manager Publications) and Dr. Faryal Sami (Assistant Manager).

Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK




Contributor(s):
Claudio Sorio
Section of General Pathology, Department of Medicine
University of Verona
Italy


José Perdomo
Haematology Research Unit, St George and Sutherland Clinical School
University of New South Wales
Australia


Krishna Kanth Pulicherla
Department of Science and Technology, Ministry of Science and Technology, Govt. of India, Technology Bhavan, New Mehrauli Road
New Delhi-110016
India


Massimiliano Bonifacio
Section of Hematology, Department of Medicine
University of Verona
Italy


Naga Ramya Lanka
Acharya Nagarjuna University
Nagarjuna Nagar, Guntur-522510
India


Natasha Ali
Department of Pathology & Laboratory Medicine/Oncology, Aga Khan University
Karachi
Pakistan


Ota Fuchs
Institute of Hematology and Blood Transfusion
U Nemocnice 1, 128 20 Prague 2
Czech Republic


Rajiv K. Saxena
Faculty of Life Sciences and Biotechnology, South Asian University
New Delhi
India


Sreoshi Chatterjee
School of Life Sciences, Jawaharlal Nehru University
New Delhi
India




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