New Concepts in Stroke Diagnosis and Therapy

Book Series: Current Developments in Stroke

Volume 1

by

Alberto Radaelli, Giuseppe Mancia, Carlo Ferrarese, Simone Beretta

DOI: 10.2174/97816810842131170101
eISBN: 978-1-68108-421-3, 2017
ISBN: 978-1-68108-422-0
ISSN: 2542-5110 (Print)
ISSN: 2542-5129 (Online)



Indexed in: EBSCO.

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such...[view complete introduction]

Intracerebral Bleeding and Oral Anticoagulant Therapies: Clinical Relevance and Management

- Pp. 85-111 (27)

Monica Carpenedo

Abstract

Vitamin K antagonists such as warfarin and acenocumarol are the most widely used oral anticoagulants. Their clinical indications include both stroke prevention and prophylaxis and treatment of venous thromboembolism. Intracerebral hemorrhage (ICH) is the most important side effect of anticoagulant therapy accounting for almost 20% of all ICH. Non vitamin K anticoagulants or direct oral anticoagulants (DOACs) have been recently introduced in clinical practice due to their practical advantages over VKA. They are at least as effective as warfarin in the management of thromboembolic diseases and in the thromboprophylaxis of non-valvular atrial fibrillation, moreover, they have a more favorable safety profile. The present chapter will focus on vitamin K antagonists and DOACs mechanisms of action, on their pharmacokinetics and pharmacodynamics, and on the relative risk of bleeding during treatment.

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