Toward the Future: The New Challenges of the Cell Therapy and Potential of Regenerative Medicine


by

Nicola Daniele

DOI: 10.2174/97816810843741170101
eISBN: 978-1-68108-437-4, 2017
ISBN: 978-1-68108-438-1



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Cells are the building blocks of life and some cells (stem cells) have the ability to produce other cells through the processes of cel...[view complete introduction]

Table of Contents

Foreword

- Pp. i-ii (2)

Entela Shkembi

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Preface

- Pp. iii-iv (2)

Nicola Daniele and Francesco Zinno

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List of Contributors

- Pp. v-vi (2)

Nicola Daniele and Francesco Zinno

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Biology of Human Stem Cells

- Pp. 3-9 (7)

Silvia Franceschilli

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Hematopoietic Stem Cells: Identification, Properties and Interest for Clinical Applications

- Pp. 10-19 (10)

Nicola Daniele, Francesco Zinno and Federica Tomassetti

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Stem Cell Therapy Applications: The Challenge of Regenerative Medicine

- Pp. 20-30 (11)

Fulvia Fraticelli

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Pluripotent Stem Cells: Basic Biology and Translational Medicine

- Pp. 31-55 (25)

Filippo Zambelli, Lucia De Santis and Rita Vassena

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Exploiting the Role of Hematopoietic Stem Cell Transplantation as a Cure of Hematological and Non Hematological Diseases

- Pp. 56-104 (49)



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Human Induced Pluripotent Stem Cells-Based Strategies: New Frontiers for Personalized Medicine

- Pp. 105-141 (37)

Rosa Valentina Talarico, Giuseppe Novelli, Federica Sangiuolo and Paola Spitalieri

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Stem Cells for Therapeutic Delivery of Mediators and Drugs

- Pp. 142-157 (16)

Pranela Rameshwar, Jimmy Patel and Alexander Aleynik

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Subject Index

- Pp. 158

Nicola Daniele and Francesco Zinno

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Foreword

As a woman first, and as passionate researcher second, I was always attracted by what did represent Marie Curie and her breakthroughs for the entire scientific world. One of my favorite quotes is:

“We must not forget that when radium was discovered no one knew that it would prove useful in hospitals. The work was one of pure science. And this is a proof that scientific work must not be considered from the point of view of the direct usefulness of it. It must be done for itself, for the beauty of science, and then there is always the chance that a scientific discovery may become like the radium a benefit for mankind”

Marie Curie



For me this means that as researcher we must find passion in what we make to trigger the “out of the box” thinking and to realize the unimaginable. When I was a student I meet two distinguished researchers Francesco Zinno, and Nicola Daniele whom introduced me with the main goals of the hematopoietic stem cells (HSCs) manipulation processes. Cell therapy helped the mass implementation of one the breakthrough that changed the way of making medicine, the regenerative medicine. Regenerative medicine involves the use of some of the most advanced therapeutic technologies of the 21st century. We can define this branch of medicine as methods to replace or regenerate human cells, tissues or organs in order to restore or establish normal function with the use of cell therapies, tissue engineering, gene therapy and biomedical engineering techniques [1]. The rapid pace of the supporting science is likely to see its application across ever increasing fields of clinical practice. This book’s main aim is to ponder on the importance of the regenerative medicine under the success that this area was given by stem cell research, and cell- and gene-based therapy. To start this journey, authors decided to give a general picture of the biology of human stem cells and their classification, to introduce the reader with their unique and extraordinary properties. After that, they continued with a typology-based structured analysis of the potentiality of these cells to upgrade the therapeutic treatments.

They explain better the actual use of the stems cells and stems cells-like for regenerative therapeutic purpose such as:

• Cell-therapy approaches in neurologic areas such as Parkinson’s disease;

• Retinal repair;

• Optic nerve regeneration;

• Reconstruction of the tissues in cases of burn;

• Bladder repair;

• Liver diseases;

• Angiogenesis and cardiac repair.

Authors continued with the researches that aim to reach and overstep the actual bounders of the “personalized medicine” to underline the stage of evolution and the infinite possibility of this new outstanding way of thinking on medicine. This book outline an attractive promotion of the present and future benefits of mankind from the discovery of stems cells and their use on the regenerative medicine. The more we know about stems cells the more we approach with the potentiality of human body to heal its self.

Entela Shkëmbi
Semiology Laboratory Manager
Dani Infertility Clinic
Tirana,Albania

[1] “Building on our own potential: a UK pathway for regenerative medicine” A report from the Regenerative Medicine Expert Group


Preface

This eBook entitled “Toward the Future: The New Challenges of the Cell Therapy and Potential of Regenerative Medicine” comprises chapters written by the leading experts in this field that provide state-of-the art information about the developments in important selected areas of Regenerative Medicine.

Regenerative Medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects.



This field holds the promise of regenerating damaged tissues and organs in the body by stimulating previously irreparable organs to heal themselves.

Regenerative Medicine also empowers scientists to grow tissues and organs in the laboratory and safely implant them when the body cannot heal itself.

Importantly, Regenerative Medicine has the potential to solve the problem of the shortage of organs available through donation compared to the number of patients that require life-saving organ transplantation.

Regenerative Medicine is also one of the fastest growing biomedical industries in the world because patients are being cured of diseases that were once incurable. Moreover, this field represents a new paradigm in human health because the vast majority of treatments for chronic and life-threatening disease focus on treating the symptoms, not curing the disease.

In fact, there are few therapies in use today capable of curing or significantly changing the course of a disease.

Stem cell therapy, when combined with immune and gene therapy, shows even greater potential to cure diseases. This new combination of regenerative cell therapies will open a new age of medicine, forever changing how it is practiced.

We would like to express our gratitude to all the Authors for their excellent contributions. We would also like to thank the entire team of Bentham Science Publishers, particularly Dr. Humaira Hashmi and Prof. Atta-ur-Rahman for their excellent efforts. We are confident that this Volume will receive wide appreciation from students and researchers.

Dr. Nicola Daniele
Editor

Cryolab
University of Rome “Tor Vergata”
Rome
Italy


Prof. Francesco Zinno
Editor

Faculty of Medicine and Cryolab
University of Rome “Tor Vergata”
Rome
Italy


Dr. Claudio Pellegrini
Assistant Editor

Cryolab
University of Rome “Tor Vergata”
Rome
Italy


List of Contributors

Editor(s):
Nicola Daniele




Contributor(s):
Alexander Aleynik
Graduate School of Biomedical Health Sciences, Rutgers Univ.
Newark, NJ
USA


Carla Cerri
Pediatric Oncology Hematology Unit, Perugia General Hospital, Località Sant'Andrea delle Fratte
06156 Perugia
Italy


Elena Mastrodicasa
Pediatric Oncology Hematology Unit, Perugia General Hospital, Località Sant'Andrea delle Fratte
06156 Perugia
Italy


Federica Sangiuolo
Department of Biomedicine and Prevention, Tor Vergata University
00133 Rome
Italy


Federica Tomassetti
CryoLab, Centre of Biotechnology and Cryobiology
Rome
Italy


Filippo Zambelli
Vrije Universiteit Brussel, Research Group Reproduction and Genetics, Brussels, Belgium and S.I.S.Me.R. Reproductive medicine Unit
Bologna
Italy


Francesco Arcioni
Pediatric Oncology Hematology Unit, Perugia General Hospital, Località Sant'Andrea delle Fratte
06156 Perugia
Italy


Francesco Zinno
CryoLab, Centre of Biotechnology and Cryobiology, Rome, Italy and Immunohaematology Section, Tor Vergata University
Rome
Italy, and Az. Ospedaliera di Cosenza


Fulvia Fraticelli
CryoLab, Centre of Biotechnology and Cryobiology
Rome
Italy


Giuseppe Novelli
Department of Biomedicine and Prevention, Tor Vergata University
00133 Rome
Italy


Grazia Maria Immacolata Gurdo
Pediatric Oncology Hematology Unit, Perugia General Hospital, Località Sant'Andrea delle Fratte
06156 Perugia
Italy


Ilaria Capolsini
Pediatric Oncology Hematology Unit, Perugia General Hospital, Località Sant'Andrea delle Fratte
06156 Perugia
Italy


Jimmy Patel
New Jersey Medical School, Dept of Medicine, Hematology/Oncology
New Jersey Medical School, USA


Katia Perruccio
Pediatric Oncology Hematology Unit, Perugia General Hospital, Località Sant'Andrea delle Fratte
06156 Perugia
Italy


Lucia De Santis
San Raffaele Scientific Institute, Vita-Salute University, Dept Ob/Gyn, IVF Unit
Milan
Italy


Maurizio Caniglia
Pediatric Oncology Hematology Unit, Perugia General Hospital, Località Sant'Andrea delle Fratte
06156 Perugia
Italy


Nicola Daniele
CryoLab, Centre of Biotechnology and Cryobiology
Rome
Italy


Paola Spitalieri
Department of Biomedicine and Prevention, Tor Vergata University
00133 Rome
Italy


Pranela Rameshwar
New Jersey Medical School, Dept of Medicine, Hematology/Oncology
New Jersey Medical School, USA


Rita Vassena
Clinica EUGIN
Barcelona
Spain


Silvia Franceschilli
CryoLab, Centre of Biotechnology and Cryobiology
Rome
Italy


Valentina Rosa Talarico
Department of Biomedicine and Prevention, Tor Vergata University
00133 Rome
Italy




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