Frontiers in Clinical Drug Research – Diabetes and Obesity

Volume 4

by

Atta-ur-Rahman

DOI: 10.2174/97816810844591170401
eISBN: 978-1-68108-445-9, 2019
ISBN: 978-1-68108-446-6
ISSN: 2467-9607 (Print)
ISSN: 2352-3220 (Online)



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Table of Contents

Preface

- Pp. i
Atta-ur-Rahman
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List of Contributors

- Pp. ii-iii (2)
Atta-ur-Rahman
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Pharmacologic Obesity Treatment – Emphasis on Efficacy and Cardiometabolic Markers

- Pp. 1-19 (19)
Fariha Salman, Ivan Gerling and Helmut O. Steinberg
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Interplay Between Bile Acid and GLP-1 Receptor Agonist Signaling Informs the Design of Drugs to Combat Obesity and its Metabolic Complications

- Pp. 20-57 (38)
Jessica Felton and Jean-Pierre Raufman
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Sodium–Glucose Co-Transporters Inhibitors for Type 2 Diabetes Mellitus: The ‘New Kids on the Block’ in the Era of Evidence-based Medicine

- Pp. 58-107 (50)
Cheow Peng Ooi, Norlaila Mustafa, Nor Azmi Kamaruddin and Munn Sann Lye
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The Effects of Traditional Chinese Medicine on Inflammatory Cytokines in Diabetic Nephropathy: The Progress in the Past Decades

- Pp. 108-134 (27)
Xiang Tu, Yuan Ping Deng, Ming Chen, James B. Jordan and Sen Zhong
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Through the Perspective of Histology - The Alzheimer’s Disease Promotion by Obesity and Glucose Metabolism: Type 3 Diabetes

- Pp. 135-198 (64)
Cigdem Elmas and Cemile Merve Seymen
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Pharmacological Mechanism of PPARγ Ratio in Diabetes and Obesity

- Pp. 199-225 (27)
Jose Roberto Santin, Marina Jagielski Goss and Nara Lins Meira Quintao
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Hydrogen Sulfide and Carbohydrate Metabolism

- Pp. 226-258 (33)
Zahra Bahadoran, Parvin Mirmiran and Asghar Ghasemi
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Subject Index

- Pp. 259-266 (8)
Atta-ur-Rahman
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Preface

This volume of the eBook series entitled: Frontiers in Clinical Drug Research – Diabetes and Obesity presents some recent exciting developments in clinical trials and formulation of research plans in the field of diabetes and obesity. The book should prove to be a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials.

The chapters are written by authorities in the field and are mainly focused on obesity treatment. They include contributions on cardiometabolic markers, bile acid and GLP-1 receptor agonists to combat obesity and its metabolic complications, sodium-glucose co-transporter inhibitors for type 2 diabetes mellitus, the effects of traditional Chinese medicine on inflammatory cytokines in diabetic nephropathy, Alzheimer’s disease promotion by obesity and glucose metabolism, pharmacological mechanism of PPARγ ratio in diabetes and obesity, and the metabolism of hydrogen sulfide and carbohydrate.

I hope that the readers will find these reviews valuable and thought-provoking so that they may trigger further research in the quest for new developments in the field. I am thankful to the efficient team of Bentham Science Publishers especially Dr. Faryal Sami (Manager Publications), Mr. Shehzad Iqbal Naqvi (Editorial Manager Publications) and Mr. Mahmood Alam (Director Publications).

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Kings College, University of Cambridge
Honorary Life Fellow
Cambridge
UK




Contributor(s):
Asghar Ghasemi
Endocrine Physiology Research Center, Research Institute for Endocrine Sciences
Shahid Beheshti University of Medical Sciences
Tehran
Iran


Cemile Merve Seymen
Department of Histology and Embryology, Faculty of Medicine
Gazi University
Ankara
Turkey


Charmaine Gentles
North Shore University Hospital
Manhassett, NY
USA


Cheow Peng Ooi
Endocrine Unit, Department of Medicine, Faculty of Medicine and Health Sciences
Universiti Putra
Malaysia


Cigdem Elmas
Department of Histology and Embryology, Faculty of Medicine
Gazi University
Ankara
Turkey


Dominick Gadaleta
North Shore University Hospital
Manhassett, NY
USA


Fariha Salman
Department of Internal Medicine
University of Tennessee Health Science Center
Memphis, TN
USA


Helmut O. Steinberg
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism
University of Tennessee Health Science Center
Memphis TN
USA


Ivan Gerling
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism
University of Tennessee Health Science Center
Memphis TN
USA


James B. Jordan
National Traditional Chinese Medicine Clinical Research Base for Diabetes Mellitus/Teaching Hospital of Chengdu University of Traditional Chinese Medicine
Sichuan Province
China


Jean-Pierre Raufman
Department of Medicine
University of Maryland School of Medicine
Baltimore, MD
USA


Jessica Felton
Department of Surgery
University of Maryland School of Medicine
Baltimore, MD
USA


José Roberto Santin
Postgraduate Program of Pharmaceutical Science
Universidade do Vale do Itajaí
Itajaí, Santa Catarina
Brazil


Larry Gellman
North Shore University Hospital
Manhassett, NY
USA


Marina Jagielski Goss
Postgraduate Program of Pharmaceutical Science
Universidade do Vale do Itajaí
Itajaí, Santa Catarina
Brazil


Ming Chen
Department of Nephrology, Teaching Hospital of Chengdu University of Traditional Chinese Medicine
Sichuan Province
China


Munn Sann Lye
Department of Community Health, Faculty of Medicine and Health Sciences
Universiti Putra
Malaysia


Nara Lins Meira Quintão
Postgraduate Program of Pharmaceutical Science
Universidade do Vale do Itajaí
Itajaí, Santa Catarina
Brazil


Nor Azmi Kamaruddin
Endocrine Unit, Department of Medicine, Faculty of Medicine
National University of Malaysia
Malaysia


Norlaila Mustafa
Endocrine Unit, Department of Medicine, Faculty of Medicine
National University of Malaysia
Malaysia


Parvin Mirmiran
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences
Shahid Beheshti University of Medical Sciences
Tehran
Iran


Sen Zhong
National Traditional Chinese Medicine Clinical Research Base for Diabetes Mellitus/Teaching Hospital of Chengdu University of Traditional Chinese Medicine
Sichuan Province
China


Xiang Tu
National Traditional Chinese Medicine Clinical Research Base for Diabetes Mellitus/Teaching Hospital of Chengdu University of Traditional Chinese Medicine
Sichuan Province
China


YuanPing Deng
Department of Internal Medicine, Traditional Chinese Medicine Hospital of Fushun County
Sichuan Province
China


Zahra Bahadoran
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences
Shahid Beheshti University of Medical Sciences
Tehran
Iran




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