Moulding, Extrusion, Floss and Three Dimensional Printing Technologies for Developing Fast Dissolving/Disintegrating Tablets
- Pp. 99-118 (20)Vikas A. Saharan
This chapter describes various developments in the designing, fabrication and manufacturing of FDTs using various technologies based on moulding, extrusion, floss, and three dimensional printing (3DP). Moulding has evolved from conventional moulding/tablet triturates to heat moulding, moulding methods involving use of compressed gases or low boiling point solvents, microwave drying, vacuum drying and compression of wet granules in especially designed moulding machine. Extrusion is not yet fully explored for developing FDTs. Floss techniques has moved ahead from Shearform® floss through liquiflash to creation of microparticulates. Rapid prototyping techniques, especially three dimensional printing (3DP), have enabled the use of computer aided designing (CAD) possibilities in manufacturing of highly porous dosage form offering immediate and complex drug release characteristics, tablets of any shape and dosage forms which can flash into a matter of seconds.