The Search for Antidepressants - An Integrative View of Drug Discovery

Book Series: Frontiers in Drug Discovery

Volume 2

by

Andre F. Carvalho, Gislaine Zilli Reus, João Luciano de Quevedo

DOI: 10.2174/97816810847321170201
eISBN: 978-1-68108-473-2, 2017
ISBN: 978-1-68108-474-9
ISSN: 2542-7350 (Print)
ISSN: 2214-6210 (Online)





Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disabi...[view complete introduction]

Monoamine Oxidase-A: A Valid Target for the Management of Depression

- Pp. 126-134 (9)

Bijo Mathew and Jerad Suresh

Abstract

Monoamine oxidase enzyme has been developed as a valid target for the treatment of depression. The development of selective and reversible type of monoamine oxidase-A inhibitors still remains a challenge to medicinal chemists pursuing the research towards the search of innovative chemotypes for the management of depressive states. The present chapter focuses on the history of MAO-A inhibitors, structure and biochemistry of MAO-A. It also covers challenges involved in the drug development of MAO-A inhibitors.

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