The Search for Antidepressants - An Integrative View of Drug Discovery

Book Series: Frontiers in Drug Discovery

Volume 2


Andre F. Carvalho, Gislaine Zilli Reus, João Luciano de Quevedo

DOI: 10.2174/97816810847321170201
eISBN: 978-1-68108-473-2, 2017
ISBN: 978-1-68108-474-9
ISSN: 2542-7350 (Print)
ISSN: 2214-6210 (Online)

Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disabi...[view complete introduction]
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Oxidative and Nitrosative Stress, Immune Inflammation and Trptophan Catabolites in Driving Melatonergic Pathway Alterations in Depression: Treatment Implications

- Pp. 222-241 (20)

George Anderson and Michael Maes


In this chapter we review the interactions of oxidative and nitrosative stress (O&NS), immune-inflammation, tryptophan catabolites (TRYCATs) and suboptimal mitochondrial functioning in driving changes in the melatonergic pathways in major depressive disorder (MDD). We propose that such interactive biological processes provide a framework for the development of a number of novel pharmaceutical and nutriceutical treatment targets, with relevance to a classification of MDD that is based on biological underpinnings rather than on subjective phenomenology.

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