Frontiers in Clinical Drug Research; Anti-Infectives

Volume 4

by

Atta-ur-Rahman

DOI: 10.2174/97816810848791170401
eISBN: 978-1-68108-487-9, 2017
ISBN: 978-1-68108-488-6
ISSN: 2452-3208 (Print)
ISSN: 2352-3212 (Online)



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Frontiers in Clinical Drug Research – Anti infectives is an eBook series that b...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur- Rahman

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List of Contributors

- Pp. ii-iii (2)

Atta-ur- Rahman

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Strategies to Prolong the Useful Life of Existing Antibiotics and Help Overcoming the Antibiotic Resistance Crisis

- Pp. 1-27 (27)

Marcelo E. Tolmasky

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Preparation and Perspectives of Catalytic Antibodies Possessing Characteristic Ability to Inhibit Infection Against Viruses such as Influenza and Rabies

- Pp. 28-57 (30)

Emi Hifumi, Mitsue Arakawa and Taizo Uda

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Recent Advances in the Development of Antiviral Approaches against Hemorrhagic-Fever-Causing Arenaviruses

- Pp. 58-92 (35)

Viviana Castilla, Jesus E. Brunetti, Maria N. Armiento and Luis A. Scolaro

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The New Role of Steroids in Viral Infections

- Pp. 93-141 (49)

Gabriel F. Gola, Andrea C. Bruttomesso, Andrea A. Barquero and Javier A. Ramirez

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Monoclonal Antibodies – Addressing the Challenges on the Manufacturing Processing of an Advanced Class of Therapeutic Agents

- Pp. 142-203 (62)

Emanuel V. Capela, Maria Raquel Aires-Barros, Mara G. Freire and Ana M. Azevedo

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Prevention and Eradication of Biofilm in Medical Indwelling Devices

- Pp. 204-248 (45)

Maria Manuel Azevedo, Luis Cobrado, Ana Silva-Dias, Cidalia Pina- Vaz and Acacio Goncalves Rodrigues

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Subject Index

- Pp. 249-258 (10)

Atta-ur- Rahman

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Preface

The fourth volume of Frontiers in Clinical Drug Research – Anti Infectives comprises six chapters that cover a variety of topics including, prolonging antibiotic life, biofilms in medical devices and various antiviral drugs.

In the first chapter, Tolmasky reviews pharmacological strategies that can be used to improve the efficacy of antibiotics in the body. These strategies are important in the wake of an ongoing crisis of multi-drug resistant organisms. In the second chapter, Uda et al. review the information about catalytic antibodies that can act as antiviral medicines against specific virus targets including the rabies and influenza viruses.

In chapter 3, Castilla et al. review the recent advances in drugs that target arenaviruses, pathogens that are responsible for haemorrhagic fever which is endemic to South America. In the fourth chapter, Ramírez and colleagues discuss the new role of steroids as therapeutic agents in viral infections.

In chapter 5, Freire et al., provide an overview on the production and utilization of monoclonal antibodies as therapeutic agents, including their use for treating infectious diseases. In the last chapter, Azevedo et al. discuss different proposals for combating microfilms that form in medical indwelling devices (MIDs) in the body. Advances on this front can help medical professionals and engineers in keeping such devices longer in the body. Limiting infections caused by such biofilms also has clear benefits to patients.

I hope that the readers will be pleased with the excellent and comprehensive reviews presented in this book in areas of contemporary importance.

Finally, I would like to thank all the editorial staff of Bentham Science Publishers, particularly Dr. Faryal Sami, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their technical support.

Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow,
Kings College,
University of Cambridge,
Cambridge,
UK

List of Contributors

Author(s):
Atta-ur-Rahman FRS
Kings College
University of Cambridge
Cambridge
UK




Contributor(s):
Acácio Gonçalves Rodrigues
Department of Microbiology
Faculty of Medicine, University of Porto
4200 – 319 Porto
Portugal


Ana M. Azevedo
iBB – Institute for Bioengineering and Biosciences
Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais
1049-001 Lisbon
Portugal


Ana Silva-Dias
Department of Microbiology
Faculty of Medicine, University of Porto
4200-319 Porto
Portugal
/
CINTESIS
Faculty of Medicine, University of Porto
4200-319 Porto
Portugal


Andrea C. Bruttomesso
Universidad de Buenos Aires
Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica
Buenos Aires
Argentina
/
CONICET – Universidad de Buenos Aires
Instituto de Quimica Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN)
Buenos Aires
Argentina


Cidália Pina-Vaz
Department of Microbiology
Faculty of Medicine, University of Porto
4200-319 Porto
Portugal
/
CINTESIS
Faculty of Medicine, University of Porto
4200-319 Porto
Portugal
/
Department of Microbiology
Centro Hospitalar S. João


Emanuel V. Capela
CICECO – Aveiro Institute of Materials
Chemistry Department, University of Aveiro
3810-193 Aveiro
Portugal
/
iBB – Institute for Bioengineering and Biosciences
Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais
1049-001 Lisbon
Portugal


Emi Hifumi
Oita University; Research Promotion Institute
700 Dannoharu
Oita-shi, Oita 870-1192
Japan


Gabriel F. Gola
Universidad de Buenos Aires
Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica
Buenos Aires
Argentina
/
CONICET – Universidad de Buenos Aires
Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR)
Buenos Aires
Argentina


Jesús E. Brunetti
Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires. Buenos Aires, Argentin0061 Ciudad Universitaria , Pabellón 2, Piso 4
1428 Buenos Aires
Argentina


Javier A. Ramírez
Universidad de Buenos Aires
Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica
Buenos Aires
Argentina
/
CONICET – Universidad de Buenos Aires
Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR)
Buenos Aires
Argentina


Luis A. Scolaro
Laboratorio de Virología
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires
Buenos Aires, Argentin0061 Ciudad Universitaria , Pabellón 2, Piso 4, 1428 Buenos Aires
Argentina


Mara G. Freire
CICECO – Aveiro Institute of Materials
Chemistry Department, University of Aveiro
3810-193 Aveiro
Portugal


Marcelo E. Tolmasky
Center for Applied Biotechnology Studies
Department of Biological Science, California State University Fullerton
Fullerton, CA
USA


Maria Azevedo Manuel
Department of Microbiology
Faculty of Medicine, University of Porto
4200-319 Porto
Portugal
/
CINTESIS
Faculty of Medicine, University of Porto
4200-319 Porto
Portugal


María N. Armiento
Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires. Buenos Aires, Argentin0061 Ciudad Universitaria , Pabellón 2, Piso 4
1428 Buenos Aires
Argentina


Maria Raquel Aires-Barros
iBB – Institute for Bioengineering and Biosciences
Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais
1049-001 Lisbon
Portugal


Mitsue Arakawa
Tottori College of Nursing
854 Fukuba, Kurayoshi-shi
Tottori 682-8555
Japan


Taizo Uda
Oita University
Department of Applied Chemistry; Faculty of Engineering
700 Dannoharu; Oita-shi, Oita 870-1192
Japan
/
Nanotechnology Laboratory
Institute of Systems, Information Technologies and Nanotechnologies (ISIT)
4-1 Kyudai-shinmachi; Fukuoka 879-5593
Japan


Viviana Castilla
Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires. Buenos Aires, Argentin0061 Ciudad Universitaria , Pabellón 2, Piso 4
1428 Buenos Aires
Argentina




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