HPV Infections: Diagnosis, Prevention and Treatment

by

Azam Bolhassani

DOI: 10.2174/97816810861701180101
eISBN: 978-1-68108-617-0, 2018
ISBN: 978-1-68108-618-7



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Human papillomavirus (HPV) infection is one of the most frequently sexually transmitted diseases in the world. HPV infections are resp...[view complete introduction]
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Table of Contents

Preface

- Pp. i
Azam Bolhassani
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List of Contributors

- Pp. ii
Azam Bolhassani
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General Description of HPVs

- Pp. 1-7 (7)
Kimia Kardani and Azam Bolhassani
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HPV Proteins and Their Functions

- Pp. 8-29 (22)
Kimia Kardani and Azam Bolhassani
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Types of Benign or Malignant Diseases Associated with HPV Infections

- Pp. 30-43 (14)
Kimia Kardani and Azam Bolhassani
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The Life Cycle and Transmission of HPV Types

- Pp. 44-61 (18)
Kimia Kardani, Niloofar Naderi and Azam Bolhassani
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Natural History of HPV Infections in Cancer Development

- Pp. 62-72 (11)
Niloofar Naderi, Kimia Kardani and Azam Bolhassani
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HPV-Related Cancers

- Pp. 73-85 (13)
Kimia Kardani and Azam Bolhassani
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The Epidemiology of HPV-Related Cancer Types

- Pp. 86-94 (9)
Kimia Kardani, Afshin Khavari and Azam Bolhassani
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Immunity against HPV-Related Cancers

- Pp. 95-119 (25)
Afshin Khavari, Kimia Kardani and Azam Bolhassani
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Risk Factors and Symptoms for HPV-Related Cancers

- Pp. 120-128 (9)
Kimia Kardani and Azam Bolhassani
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Diagnosis of HPV Infections, HPV Testing in Patients

- Pp. 129-158 (30)
Kimia Kardani, Elnaz Agi and Azam Bolhassani
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Prevention of HPV-Associated Diseases

- Pp. 159-163 (5)
Azam Bolhassani and Elnaz Agi
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Treatment and Follow up of HPV Infection- Related Cancers

- Pp. 164-169 (6)
Azam Bolhassani and Niloofar Naderi
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Preventive Human Papillomavirus (HPV) Vaccines: Immunogenicity, Efficacy and Safety

- Pp. 170-181 (12)
Amitis Ramezani and Arezoo Aghakhani
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Therapeutic HPV Vaccines: Immunogenicity, Efficacy and Safety

- Pp. 182-200 (19)
Azam Bolhassani
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Preclinical and Clinical Experiments on HPV Vaccines

- Pp. 201-214 (14)
Azam Bolhassani and Afshin Khavari
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Side Effects of HPV Vaccines

- Pp. 215-219 (5)
Afshin Khavari and Azam Bolhassani
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Future Prospects in HPV Prevention and Treatment

- Pp. 220-226 (7)
Azam Bolhassani
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Subject Index

- Pp. 227-236 (10)
Azam Bolhassani
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Preface

Human papillomavirus (HPV) infection is one of the most frequently sexually transmitted diseases in the world. Multiple types of HPVs are divided as low risk, and high risk types. Low risk types cause warts and high risk types can cause cancer. HPV infections are responsible for almost all cases of genital warts and cervical cancer, 90% of anal cancers, 65% of vaginal cancers, 50% of vulva cancers, 35% of penile cancers, and 60% of oropharyngeal cancers. The health guidelines are recommended for HPV testing in patients using different methods. However, there is no way of knowing how long a person has had the virus. The methods of reducing the HPV infections include sexual abstinence, condoms, vaccination and microbicides. Recently, two commercial vaccines such as Gardasil and Cervarix have been used to prevent HPV infections. There are several side effects for preventive vaccines such as swelling, redness and pain at the injection site, headaches, blood problems (bleeding), chills, dizzy, Guillain Barré syndrome, joint pain, lymphadenopathy, muscle pain or tenderness, seizures (fits), tiredness, vomiting, and weakness. In rare cases, it is possible to experience an anaphylactic reaction with related signs. Regarding the poor diagnosis of HPV infections in developing countries, the researchers have focused on therapeutic vaccines. Also, the preventive vaccines are being developed using various methods for reducing side effects and also their use against various HPV types in women and also men. The studies continue on HPV diagnosis and vaccination for eradicating all HPV-related cancers. Already, various approaches have been utilized in clinical trials for the treatment of HPV-related cancers. The aim of this book is to provide up-to-date reviews of the growing field of diagnosis, prevention and treatment in HPV-related infections. Contributions cover a large range of topics including epidemiology, molecular biology, transmission, diagnosis, prevention, and treatment along with preclinical and clinical experiments. Regarding the high prevalence of HPV infections and the absence of correct diagnosis especially in developing countries as well as high cost of preventive vaccines and low information of many people about HPVs, hopefully, this book can further clarify and provide open ways for future studies of scientists on uncertain aspects of HPV.

Dr. Azam Bolhassani
Department of Hepatitis and AIDS,
Pasteur Institute of Iran,
Tehran,
Iran

List of Contributors

Editor(s):
Azam Bolhassani
Department of Hepatitis and AIDS, Pasteur Institute of Iran
Tehran
Iran




Contributor(s):
Afshin Khavari
Department of Hepatitis and AIDS
Pasteur Institute of Iran
Tehran
Iran


Amitis Ramezani
Clinical Research Department
Pasteur Institute of Iran
Tehran
Iran


Arezoo Aghakhani
Clinical Research Department
Pasteur Institute of Iran
Tehran
Iran


Azam Bolhassani
Department of Hepatitis and AIDS
Pasteur Institute of Iran
Tehran
Iran


Elnaz Agi
Department of Hepatitis and AIDS
Pasteur Institute of Iran
Tehran
Iran


Kimia Kardani
Department of Pharmaceutical Biotechnology
School of Pharmacy, Shahid Beheshti University of Medical Sciences
Tehran
Iran


Niloofar Naderi
Department of Hepatitis and AIDS
Pasteur Institute of Iran
Tehran
Iran




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