Advances in Organic Synthesis

Volume 12

by

Atta-ur-Rahman

DOI: 10.2174/97816810868041181201
eISBN: 978-1-68108-680-4, 2018
ISBN: 978-1-68108-683-5
ISSN: 1574-0870 (Print)
ISSN: 2212-408X (Online)



Indexed in: Scopus.

Advances in Organic Synthesis is a book series devoted to the latest advances i...[view complete introduction]
US $
Buy Personal eBook
89
Order Library eBook
356
Order Printed Copy
*107
Order PDF + Printed Copy (Special Offer)
*151

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology

Progress in the Chemistry of Phosphorothioates

- Pp. 117-150 (34)

Mihaela Gulea

Abstract

The present review focuses on the synthesis and applications of phosphorothioates (phosphorothioic esters) with the general structure R2P(O)SR’, which are molecules belonging to the large family of organophosphorus compounds. They found important applications as biological active molecules, as well as synthetic intermediates to access valuable phosphorus and/or sulfur-containing structures. The reactivity of both heteroatoms, phosphorus and sulfur, is discussed by showing how they are involved as electrophilic, nucleophilic, or radical species in different transformations. The general methods for the preparation of phosphorothioates are described according to the various strategies involving P-S bond formation from one sulfur-reagent and one phosphorus-reagent, which include recent metal-catalyzed cross-coupling reactions. Particular attention is paid to synthetic applications of phosphorothioates occurring via the P-S bond cleavage, including for example anionic rearrangements and cascades, formation of sulfur-heterocycles, homolytic processes for olefins phosphorylation, and metal-catalyzed alkynes thiophosphorylation. The literature of the last two decades is covered, highlighting selected contributions in the chemistry of this class of compounds.

Purchase Chapter  Book Details

Advertisement


Webmaster Contact: info@benthamscience.net Copyright © 2019 Bentham Science