Advances in the Synthesis of Functional α-Organyl gem-Bisphosphonates for Biomedical Applications
- Pp. 200-252 (53)Vadim D. Romanenko
This chapter deals with the synthesis of α-organyl-substituted methylenebisphosphonates and focuses on compounds not having the heteroatomic substituents at the geminal carbon. We present different methodologies on the basis of the reactivity of monophosphonate and methylene 1,1-bisphosphonate systems including the Michaelis-Arbuzov and Michaelis-Becker reactions, substitutions, Michael additions, cycloaddition, as well as more specific approaches. Together with the synthetic methods, the biomedical application of the compounds is also described.