Advances in Organic Synthesis

Volume 12



DOI: 10.2174/97816810868041181201
eISBN: 978-1-68108-680-4, 2018
ISBN: 978-1-68108-683-5
ISSN: 1574-0870 (Print)
ISSN: 2212-408X (Online)

Indexed in: Scopus.

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Advances in the Synthesis of Functional α-Organyl gem-Bisphosphonates for Biomedical Applications

- Pp. 200-252 (53)

Vadim D. Romanenko


This chapter deals with the synthesis of α-organyl-substituted methylenebisphosphonates and focuses on compounds not having the heteroatomic substituents at the geminal carbon. We present different methodologies on the basis of the reactivity of monophosphonate and methylene 1,1-bisphosphonate systems including the Michaelis-Arbuzov and Michaelis-Becker reactions, substitutions, Michael additions, cycloaddition, as well as more specific approaches. Together with the synthetic methods, the biomedical application of the compounds is also described.

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