Advances in Organic Synthesis

Volume 10



DOI: 10.2174/97816810874361181001
eISBN: 978-1-68108-743-6, 2018
ISBN: 978-1-68108-744-3
ISSN: 1574-0870 (Print)
ISSN: 2212-408X (Online)

Indexed in: Scopus.

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Recent Advances in the Synthesis of N-Glycosyl Compounds

- Pp. 99-138 (40)

Nuno M. Xavier and Rafael Nunes


N-Glycosyl compounds, analogs of glycosides possessing an N-glycosidic linkage, have attracted much attention as synthetic targets in medicinal chemistry, due to their biological activities. In this chapter, the synthesis of non-nucleosidic Nglycosyl compounds is reviewed. The groups of molecules covered herein include Nglycosylamines/ amides, sulfonamides, hydrazines, phosphoramidates and Nglycosylamino acids, among other related derivatives. Methods for their access, based on the literature from the last 20 years, as well as their relevance as bioactive substances, are focused.

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