Clinical Nuclear Cardiology: Practical Applications and Future Directions

Book Series: Frontiers in Myocardia

Volume 2

by

Shinro Matsuo

DOI: 10.2174/97816810876031180201
eISBN: 978-1-68108-760-3, 2018
ISBN: 978-1-68108-761-0
ISSN: 2451-8344 (Print)
ISSN: 2451-8352 (Online)



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Nuclear cardiology is critical for the medical evaluation of patients with heart disease. Clinical Nuclear Cardiology: Practical Appli...[view complete introduction]
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Table of Contents

Foreword

- Pp. i
Seigo Kinuya
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Preface

- Pp. ii
Shinro Matsuo
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List of Contributors

- Pp. iii-iv (2)
Shinro Matsuo
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Diagnosis of Coronary Artery Disease with Myocardial Perfusion Imaging

- Pp. 1-14 (14)
Shinro Matsuo
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Gated Myocardial Perfusion Imaging and Risk- Stratification in Coronary Artery Disease and Heart Failure

- Pp. 15-28 (14)
Tomoaki Nakata, Kenji Sato and Kei Nakata
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Myocardial Viability Assessment in Predicting Prognosis and Providing Optimal Management for Ischemic Left Ventricular Dysfunction

- Pp. 29-56 (28)
Tokuo Kasai
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Cardiac Hybrid or Fusion Imaging and Future Prospective

- Pp. 57-66 (10)
Shinro Matsuo
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Positron Emission Tomography Myocardial Perfusion Imaging

- Pp. 67-86 (20)
Keiichiro Yoshinaga and Osamu Manabe
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Myocardial Perfusion Imaging and other Modalities

- Pp. 87-103 (17)
Yasuyo Taniguchi
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Fatty Acid Imaging from Basic to Clinical

- Pp. 104-146 (43)
Iichiro Osawa, Takashi Ushimi, Nanami Okano, Eito Kozawa and Ichiro Matsunari
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Recent Advances in BMIPP Imaging

- Pp. 147-175 (29)
Takashi Kudo, Altay Myssayev and Reiko Ideguchi
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Potential Uses of 123mIBG and Analogous PET Tracers to Guide Use of Cardiac Implantable Electronic Devices in Heart Failure and Associated Arrhythmias

- Pp. 176-202 (27)
Mark I. Travin
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Neurotransmitter Imaging for Cardiomyopathy and Takotsubo Syndrome

- Pp. 203-212 (10)
Takayuki Warisawa and Yoshihiro J. Akashi
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Evaluation of Cardiac Sympathetic Nerve Function using Iodine-123 Metaiodobenzylguanidine Scintigraphy

- Pp. 213-221 (9)
Hiroshi Mori and Shinro Matsuo
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Standardization of 123I-meta-iodobenzylguanidine Heart-To-Mediastinum Ratio: Technical Aspects

- Pp. 222-226 (5)
Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura and Yumiko Kirihara
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Image Diagnosis of Arteriosclerosis and Possibility of Early Intervention

- Pp. 227-234 (8)
Shinro Matsuo
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Nuclear Cardiology for the Diagnosis of Takotsubo Syndrome

- Pp. 235-244 (10)
Shinro Matsuo
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Small Rodent Animal Positron Emission Tomography/Single Photon Emission Tomography

- Pp. 245-252 (8)
Hiroshi Wakabayashi
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Subject Index

- Pp. 253-261 (9)
Shinro Matsuo
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Foreword

How can we best practice the clinical nuclear medicine? This eBook is designed to explain some methods regarding nuclear cardiology, which would be instructive for physicians and scientists. This book would tell what is nuclear cardiology, or how non-invasive imaging is used, from clinical evidences. The Nuclear cardiology has demonstrated continuous dramatic growth over 40 years. This book is composed of recent progress of the nuclear cardiology by leading physicians and scientists in this field. I am sure that this eBook would be useful for daily practice of all the physicians and scientists interested in this field.


Seigo Kinuya
Professor of Department of Nuclear Medicine
Graduate School of Medical Sciences
Kanazawa University
Kanazawa, Japan


Preface

Nuclear cardiology has demonstrated continuous growth for over 35 years, and now become important tool for evaluation of patients with heart disease. A nuclear cardiology test is one of the most commonly performed non-invasive cardiac imaging tests in hospitals for the patients with heart disease as well as echocardiography.

This book is composed of four parts by leading physicians and scientists in the field. The first part describes the perfusion scintigraphy. Myocardial perfusion imaging is an established method for the primary detection of coronary artery disease. Gated myocardial perfusion single-photon computed tomography (SPECT) is essential for the diagnosis of cardiac function. The addition of ECG-gating has allowed nuclear cardiology to expand from myocardial perfusion alone to the assessment of systolic and diastolic function.

The second part provides metabolic aspects of heart disease, including fatty acid metabolism. The heart is an active organ that requires high oxygen to maintain mechanical function. The major aim of oxygen uptake in the heart is to provide sufficient energy in the mitochondria in the myocardium. Glucose and free fatty acids are major energy sources in the myocardium. Recent advances in nuclear cardiology include fatty acid metabolic tracer of iodine-123-labeled BMIPP. I-123 BMIPP provides useful information in patients with heart disease.

The third part covers cardiac sympathetic function, including sympathetic nerve imaging. 123I-MIBG scintigraphy is now used as an important technique for studying cardiac neuronal function. 123I-MIBG shares the same uptake and storage mechanisms as norepinephrine. It is reported that the uptake-1 system is mediated by the norepinephrine transporter, and the uptake-2 system is an extra-neuronal system. 123I-MIBG imaging has an important prognostic value in patients with heart failure.

The fourth and the final part describes small animal molecular imaging, preventive medicine and Takotsubo syndrome.

Nuclear cardiology tests, including neurotransmitter imaging and metabolic imaging, are now easily preformed with new tracers to refine the diagnosis of heart disease. Nuclear cardiology studies contribute significantly to guiding management decisions for identifying cardiac risk in patients with heart disease.


Shinro Matsuo
Department of Nuclear Medicine,
Kanazawa University
Graduate School of Advanced Preventive Medical Sciences
Kanazawa, Japan

List of Contributors

Editor(s):
Shinro Matsuo
Department of Nuclear Medicine
Kanazawa University
Kanazawa
Japan
/
Graduate School of Advanced Preventive Medical Sciences
Kanazawa
Japan




Contributor(s):
Altay Myssayev
Atomic Bomb Disease Institute, Nagasaki University
Department of Radioisotope Medicine
Nagasaki
Japan


Chiemi Kitamura
FUJIFILM RI Pharma Co., Ltd.
Tokyo
Japan


Eito Kozawa
Department of Radiology
Saitama Medical University Hospital
Saitama
Japan


Hiroshi Mori
Department of Nuclear Medicine
Kanazawa University Hospital
Kanazawa
Japan


Hiroshi Wakabayashi
Assistant Professor of Nuclear Medicine
Kanazawa University Hospital
Kanazawa
Japan


Iichiro Osawa
Department of Radiology
Saitama
Japan


Ichiro Matsunari
Department of Radiology, Saitama Medical University Hospital
Professor of Division of Nuclear Medicine
Saitama
Japan


Kenji Sato
Department of Cardiology
Goryokaku Hospital
Hakodate
Japan


Kei Nakata
Sapporo Medical University School of Medicine
Sapporo
Japan


Keiichiro Yoshinaga
Director, Diagnostic and Therapeutic Nuclear Medicine
National Institutes for Quantum and Radiological Science and Technology
Chiba
Japan


Koichi Okuda
Assistant Professor Physics
Kanazawa Medical University
Uchinada
Japan


Kenichi Nakajima
Department of Nuclear Medicine
Kanazawa University Hospital
Kanazawa
Japan


Mark I. Travin
Department of Radiology/Division of Nuclear Medicine
Montefiore Medical Center, Albert Einstein College of Medicine, Bronx
New York
USA


Osamu Manabe
Department of Nuclear Medicine
Hokkaido University Graduate School of Medicine
Sapporo
Japan


Reiko Ideguchi
Department of Radioisotope Medicine
Atomic Bomb Disease Institute, Nagasaki University
Nagasaki
Japan


Shinro Matsuo
Department of Nuclear Medicine, Kanazawa University
Associate Professor of Nuclear Medicine
Kanazawa
Japan
/
Graduate School of Advanced Preventive Medical Sciences
Kanazawa
Japan
/
Clinical Professor
Kanazawa University Hospital
Kanazawa
Japan


Tomoaki Nakata
Department of Cardiology
Goryokaku Hospital
Hakodate
Japan


Tokuo Kasai
Professor of Cardiology Uonuma Kikan Hospital
Niigata University
Niigata
Japan


Takashi Kudo
Professor, Department of Radioisotope Medicine
Atomic Bomb Disease Institute, Nagasaki University
Nagasaki
Japan


Takashi Ushimi
Department of Radiology
Saitama Medical University Hospital
Saitama
Japan


Takayuki Warisawa
Imperial College London, Hammersmith Hospital
International Center for Circulatory Health, National Heart and Lung Institute
London
United Kingdom
/
Division of Cardiology, Department of Internal Medicine
St. Marianna University School of Medicine
Kawasaki
Japan


Yasuyo Taniguchi
Hyogo Brain and Heart Center
Hyogo
Japan


Yoshihiro J. Akashi
Professor, Division of Cardiology, Department of Internal Medicine
St. Marianna University School of Medicine
Kawasaki
Japan


Yumiko Kirihara
FUJIFILM RI Pharma Co., Ltd.
Tokyo
Japan




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