Topics in Anti-Cancer Research

Volume 3


Atta-ur-Rahman / Khurshid Zaman

DOI: 10.2174/97816080590891140301
eISBN: 978-1-60805-908-9, 2014
ISBN: 978-1-60805-909-6
ISSN: 2468-5860 (Print)
ISSN: 2213-3585 (Online)

Indexed in: Book Citation Index, Science (BKCI-S), Chemical Abstracts, BIOSIS Previews, EBSCO, Ulrich's Periodicals Directory.

This is the third volume of the Patent eBook Series entitled Topics in Anti-Cancer Research. This eBook comprises updated reviews on t...[view complete introduction]
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TRAIL Receptor-Induced Cell Death Regulation: An Update to Our Deadly Discussion

- Pp. 3-36 (34)

Olivier Micheau, Sarah Shirley and Alexandre Morizot


The use of TRAIL/APO2L, monoclonal antibodies or peptidomimetics targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs, in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature chapter is an update to our article ‚ÄúRegulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion‚ÄĚ, published in the journal ‚ÄėRecent Patents on Anti-Cancer Drug Discovery‚Äô, Volume 6, Number 3, September, 2011, Page 311 to 323, reviewing TRAIL DISC components that have been shown to regulate tumor cell fate upon TRAIL engagement.

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