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Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications
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Author: Sharmila Fagoonee

Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications

Special Offer (PDF + Printed Copy): US $28
Printed Copy: US $28
ISBN: 978-981-5040-11-1 (Print)
ISBN: 978-981-5040-10-4 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150401041210101
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Introduction

Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications covers current knowledge about stem cell delivery for cell-based therapeutics. Starting with an introduction to stem cell technology, the book provides information about the main mesenchymal stem cell (MSC) delivery routes and the cell carrier materials used for delivering the cells. The main delivery routes include the liver, the kidney and the ocular surface. This introductory information is followed up with general information about stem cell based therapeutics, covering relevant topics such as the secretome and optimal delivery strategies in cell-based therapeutics. The book then progresses into the topic of in vivo cell tracking methods in preclinical and clinical studies with specific emphasis on the liver, ocular surface and kidney while also covering factors that affect the residence time, viability, and homing of MSCs with respect to the targeted location. The discussions in these chapters are accompanied by key descriptions of MSC-based therapeutic applications in rodent models and human clinical studies. The advantages and bottlenecks in clinical MSC application, and ways to improve the therapeutic efficacy of transplanted cells are also presented, rounding up the contents of the book.

Key Features

  • - A comprehensive summary of stem cell delivery for cell-based therapeutics, suitable for a broad range of readers
  • - 10 sequential chapters that enhance the reader’s understanding on the subject
  • - An Introduction to stem cell technology
  • - Coverage of 3 key stem cell transplantation routes (liver, kidney and eye)
  • - Coverage of in vivo stem cell tracking
  • - Inclusion of basic information about MSC delivery and methods of clinical applications
  • - Discussions about preclinical mouse models
  • - A perspective on stem cell bottlenecks and recent advances in biomedical engineering that enhance the clinical application of MSCs

The contents are adapted to suit readers learning about advanced stem cells therapies at all academic levels, including undergraduates, lecturers, as well as those who are curious to understand more about the importance of stem cells, and their application in cell-based therapeutics. Professionals involved in allied fields in clinical research, and biomedical engineering will also gain a substantial understanding about regenerative medicine and cell transplantation.

Audience: undergraduates, lecturers, clinical researchers, biomedical engineers (medicine, tissue engineering) and general readers interested in stem cells, and their application in cell-based therapeutics.


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Foreword

It is a great pleasure to present “Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications”, a book that focuses on different strategies for stem cell delivery in pre-clinical models and clinical trials. This book provides a very focused and complete overview of the topic, and will certainly be of great utility for researchers and clinicians involved in stem cell therapeutic application. The book is written by Dr. Sharmila Fagoonee, a brilliant scientist with a long-standing experience in Regenerative Medicine. In particular, the researcher’s experience on stem cell administration in pre-clinical murine models of liver, kidney and ocular pathologies is reflected by the specific deepening of the stem cell delivery in those pathologies.

The book reflects the state-of-the-art knowledge on stem cell administration that involves not only stem cell therapies, but also the more recent involvement of stem cell bioproducts, such as extracellular vesicles. Indeed, stem cell-derived extracellular vesicles, and in particular mesenchymal stromal cell (MSC)-derived vesicles, are considered to mediate several of the beneficial effects of stem cell therapies. The book also takes into account labelling, biodistribution and tracking of stem cells, and the hurdles involved. The main possible routes of administration within the circulation or intra-tissue are depicted for liver and kidney, as a paradigm of parenchymal organs. Moreover, the book takes into consideration the administration routes inside the different ocular compartments, as eyes appear for their accessibility of particular relevance in stem cell research.

Finally, the clinical aspects of stem cell delivery for clinical trials are presented. Among several possible applications, a whole sub-chapter is dedicated to MSC-based therapeutics for COVID-19, considering how this emergency expanded the use of stem cells in the clinic. Indeed, proper stem cell/extracellular vesicle delivery is of utmost importance for their activity, and the main setbacks and solutions for improving MSC clinical application are also outlined.

I am convinced that this book will greatly help researchers and clinicians involved in cell therapies, who will benefit from the knowledge mentioned and illustrated in the book.



Benedetta Bussolati
Prof. of Laboratory Medicine
President of the Italian Society for Extracellular Vesicles
University of Torino
Italy